I was on exenatide same type of daily short term GLP1 injection.
GLP1 affects the Vegas nerve and for me caused me to retain food for 3 days.. before it was a healthy 14hrs.
Worked great initially for the meal you injected it.. easy to inject with a pen but after a while I started to resent it..
as I felt bloated and started feeling very tired after taking the injection. It made me lose out /waste time.
After 3 months I stopped, but the bloated slow digestion didn't ..
went thru a whole year of complaining and nearly daily enemas before I got some thing to restart my gastric function/peristaltic wave. And then got shingles due to that drug. Doh.
that was nearly 3 years ago.. Have an appointment with GI department in October.. :-?
I personally think daily GLP1 is short sighted solution which interferes with a vital nerve the Vegas nerve.
It is your second brain with as many neurons as a cat's brain. It controls your peristaltic wave (stomach/throat/gut intestines), influences your heart, ghrelin production (satiety) and another hormone to make you hungry. It is also the interface between your brain and your gut flora using proteins, hormones etc.
The Vegas nerve is an important nerve you shouldn't mess with.
That's why motilium now needs a prescription.
If you are thinking of GLP1, I'd go for the weekly injections as they have an overall effect with long lasting GLP1 and lowering blood sugar for all meals. Lot harder to ge a GP to give tho. Not many get it.
Interesting fact.. GLP1 has been found to be produced by gut bacteria in the first part of the intestines.
I am trying to do the 600kcal diet.. after using Farxiga for long time.
People mention losing your appetite.. I think that this is not due to GLP1 but a natural reflex when you eat less and drink more.
You just have to get past a couple of days and you start not to crave as much.
How many people taking daily GLP1 are constipated have longer gastric function, feel tired after injecting & eating, difficulty swallowing?
In the end I felt I was being water boarded drinking from a water bottle.