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Dianeelizabeth

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Was diagnosed as type 2 in 2019. Well controlled with low carb. Two years ago was told l have Old Dominion/ Burton upon Trent sub type. Can’t get much info on it,anyone help? 3 brothers have same.
 
Hi and welcome

I think this isn't actually a variety of Type 2 diabetes, but relates to a rare haemoglobin type. It seems to be commoner in people with Scots-Irish ancestry. Where it relates to Type 2 diabetes is that it can affect HbA1c results - so that Hba1c values are "spuriously" inflated. There are a number of factors and conditions that can mean the HbA1c test is not reliable for T2 diagnosis, and this is one of them.

The attached paper might help.

Hemoglobin Old Dominion/Burton-upon-Trent, beta 143 (H21) His-->Tyr, codon 143 CAC-->TAC--a variant with altered oxygen affinity that compromises measurement of glycated hemoglobin in diabetes mellitus: structure, function, and DNA sequence - PubMed

A hitherto unrecognized hemoglobin variant, encountered in four unrelated persons of Irish or Scots-Irish ancestry, hemoglobin Old Dominion/Burton-upon-Trent, beta 143 (H21) His-->Tyr, has now been characterized at the molecular, structural, and functional levels. Although it is associated with a …
pubmed.ncbi.nlm.nih.gov
 
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