Doddymanu
Member
Can low folate as I have been prescribed cause high Blood sugar
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Low folate
- Thread starter Doddymanu
- Start Date
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- 4,026
- Type of diabetes
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- Diet only
Hi
No personal knowledge or experience. I had a Google. There are a number of bits of published research around which might indicate that there is some impact on blood glucose levels related to raising folate or folic acid levels. This is just one, pulling together a number of studies.
www.ncbi.nlm.nih.gov
So - according to this, some reduction in fasting BG levels, fasting insulin and HOMA-IR (insulin resistance), no impact on HbA1c. They say: "Folic acid supplementation significantly reduces some markers of glycemic control in adults. These reductions were small, which may limit clinical applications for adults with type II diabetes. Further research is necessary to confirm our findings".
Studies have looked at whether low folate can cause high BG. This is one, from China (some Chinese research may be suspect) and on mice, not humans.
www.ncbi.nlm.nih.gov
This is a meta analysis of a number of RCTs:
The overall take is that there appears to be something going on relating folate to blood glucose but "more research is needed."
No personal knowledge or experience. I had a Google. There are a number of bits of published research around which might indicate that there is some impact on blood glucose levels related to raising folate or folic acid levels. This is just one, pulling together a number of studies.
Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials
Background: There is a growing interest in the considerable benefits of dietary supplementations, such as folic acid, on the glycemic profile. We aimed to investigate the effects of folic acid supplementation on glycemic control markers in adults. Methods: ...
www.ncbi.nlm.nih.gov
So - according to this, some reduction in fasting BG levels, fasting insulin and HOMA-IR (insulin resistance), no impact on HbA1c. They say: "Folic acid supplementation significantly reduces some markers of glycemic control in adults. These reductions were small, which may limit clinical applications for adults with type II diabetes. Further research is necessary to confirm our findings".
Studies have looked at whether low folate can cause high BG. This is one, from China (some Chinese research may be suspect) and on mice, not humans.
Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice
Previous studies have shown that folate levels were decreased in patients with type 2 diabetes (T2D) and further lowered in T2D patients with cognitive impairment. However, whether folate deficiency could cause T2D and subsequent cognitive dysfunction ...
www.ncbi.nlm.nih.gov
This is a meta analysis of a number of RCTs:
The overall take is that there appears to be something going on relating folate to blood glucose but "more research is needed."
