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Message: <blockquote data-quote="Oldvatr" data-source="post: 2642513" data-attributes="member: 196898">Part 2 of a rant from an armchair pipesmoking endo-no-wannabe.If we again assume the claims made for the MD diet to be true, then we must consider the claim that MD plan reduces Insulin Resistance (IR)Now the ND study used an MRI scanner to actually measure the fat content in the pancreas, and .separate out the ectopic fat from the normal fat.  They showed that a very low cal diet could reduce the ectopic fat quite quickly, and also at the same time established that the diet also improved first phase insulin response, and they made the connection between the two.  so there is evidence that diets can indeed improve IR in T2D.The ND diet is not only Low Calorie, it is also at the same time Low Carb, so I can see mechanisms that could be at play that make their claim viable.  But I do not see any mechanism in the MD diet due to the High Carb load especially in the liver which is what the MD claim is the source of the IR.  The liver is a glucose store, not a lipid store.  It is responsible for creating LDL and HDL and recycling lipids, but it is not a store.  it generates de novo lipogenesis too, but does not store them.  so why would a low fat diet clear out ectopic fat which is rogue fat in the wrong place.  All I can thnk of is that the body is scavenging to make the replacement FFA and that it is the de novo genesis process that clears the IRBut the ND diet only demonstrated IR in one organ, the pancreas.  It has been known for a long time that T2D is mainly a muscle IR phenomenon, and so there are two types of IR that need to be removed before Remission is truly dealt with.  Since muscles are mainly glucose orientated and heavily dependant on insulin, then this IR is harder to tackle and IMO i don;t think we have a solution yet.</blockquote>

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