Hi all, I wonder if anyone can shed some light on this for me. Does metformin work in the stomach, the intestines, or once absorbed into the blood - or all of those? I've been taking two tablets a day this week, going up to three next week. I still feel absolutely fine, no side effects. I would like to take it at the optimum time, and from the little bit I've read so far I gather it delays stomach emptying (thus reducing appetite and giving insulin longer to get going) but also acts at the cellular level and reduces glucose production by the liver? There are numerous other things on google searches, but advice on when to take the tablets varies. One source said it works fine on an empty stomach (although perhaps unless it's the slow release version it won't affect stomach emptying then) but if the stomach is upset by it it's better to take it with food. I don't seem to have the side effects, at least yet, so would it be more effective at reducing the effect of high morning blood sugar (high fasting level) which I seem to suffer from more than anything, to take it on an empty stomach before bed? And to optimise the appetite reduction, perhaps take the morning one just before eating? I will experiment with it, but wondered if anyone has this sussed out already.