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Metformin and Anemia?

Discussion in 'Type 2 Diabetes' started by CDudley, May 15, 2016.

  1. CDudley

    CDudley Type 2 · Active Member

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    Does anyone knows if Metformin can cause anemia? I am so tired and keep getting chest infections
     
  2. Totto

    Totto Type 2 · Well-Known Member

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    Metformin can cause B12 deficiency.

    It's also more common in diabetics to have hypothyroidism.

    Go and get checked, including Ferritin, Hb and vitamin D.
     
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  3. Liam1955

    Liam1955 Type 2 · Master

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    @CDudley - Metformin does not cause Aneamia, already challenged my GP about this, but it can cause B12 deficiency as the previous post has said. (Totto)
    However, I do have Aneamia and I get my Ferritin Levels checked for Iron count every 3 Months, and I take Iron tablets daily that I get on Prescription.

    P.S. Forgot to say I have been taking Metformin for 15 years now.
     
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    #3 Liam1955, May 16, 2016 at 12:04 PM
    Last edited by a moderator: May 16, 2016
  4. Mars1946

    Mars1946 Type 2 · BANNED

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    If You have used Metformin for a long period, then you have probably to low Cobalamin ( B12 ) vitamin.

    The treatment is with injections of B12 vitamin or with B12 tablets.

    Ask Your Doctor for help. He or she can make a blood analysis for B12, cobalamin.

    Have a nice day
     
    #4 Mars1946, May 16, 2016 at 12:44 PM
    Last edited by a moderator: May 19, 2016
  5. Hanny 66

    Hanny 66 Type 2 · Member

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    I have been type 2 for 22 years and on insulin for last three years as well as metformin. I became anemic about 10 years ago had all the tests but never found a cause. At first I had iron infusions every 6 months for three years. Now on iron tablets. Then three years ago I was told I was B12 deficient as well due to metformin which stops your gut absorbing B12 so am now on B12 tablets as well.
     
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  6. Mars1946

    Mars1946 Type 2 · BANNED

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    The poorly absorption of B12 vitamin (Cobalamin) is because the Gaster Ventriculus parietal cell do not produce Intrinsic factor . This IF must be in the gut to bind to the B12 molecule. If IF is absent then you have a poorly absorption of B12.

    Now you take B12 tablets. Normally you shod take Calcium tablets together with Metformin. Many doctors do not know about that, but it is recommended in the Endocrinology literature.
     
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  7. Mars1946

    Mars1946 Type 2 · BANNED

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    It is true that Metformin do not cause direct anaemia. The deficiency of cobalamin B12 vitamin can be the reason for anaemia perniciosa, macrocytaer anaemia. Metformin can cause deficiency of B12 vitamin and the result can be uptake to anaemia perniciosa. Its all my friend.
     
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    #7 Mars1946, May 17, 2016 at 1:41 PM
    Last edited by a moderator: May 19, 2016
  8. Mars1946

    Mars1946 Type 2 · BANNED

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    Dear Galja

    Reasons for B12 deficiency are many. One of them can be use of Metformin.
    I use on my own Metformin and the amount of Cobalamin (B12) has been of about 387 pmol/l.
    After I use the B12 tablets (CyanoCobalamin) the number has improved.

    Ask your doctor for advices.

    Have a nice day
     
  9. I use these dairy free sublingual tabs. I buy them in the UK, but they are also sold in the USA ( I am not deficient, but am on metformin)

    http://www.amazon.com/Source-Natura...463679329&sr=8-3&keywords=source+naturals+b12
     
  10. Mars1946

    Mars1946 Type 2 · BANNED

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    Hi Galja

    I am from Denmark. I know about sublingual tablets, but this therapy is obtainable in Sweden. In Demark you can get injections by the doctor of cyanoCobalamin or tablets of the same .

    This sublingual tabs are of over dose. Persons who have B12 deficiency there parietal cells in the GV (Gaster Ventriculus) do not produce the Intrinsic Factor ( IF ) and it is not possible in the intestine to absorb B12. An over dose of B12 as sublingual tablets sometime help. But all that is the choice of the patient and the doctors advices. If the B12 is very low, then there will be developed a Pernicious Anaemia.
    The blood red bodies will be very big and not able to transport oxygen to the tissues.

    Latin : Memento Vivere ( Stay in life) and be happy.


    Edited by Moderator.
     
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    #10 Mars1946, May 19, 2016 at 8:02 PM
    Last edited by a moderator: May 22, 2016
  11. Mars1946

    Mars1946 Type 2 · BANNED

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    Hi Avocado

    If you do not have deficiency of B12 and you use Metformin then in the Endocrinology literature some expert say the persons who use Metformin they shod use it together wit tablets of calcium ( chalk ). Try to do it, it will not harm you.

    Have a nice afternoon
     
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  12. Mars1946

    Mars1946 Type 2 · BANNED

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    Hi Galja
    Thanks for the links to the NCBI. This article describes the problem.
    In the article and what your doctor has informed you about B12 is not complete information about B12.
    By the adult people the organisms total amount of cobalamin B12 is about 5 - 10 mg. One part of this depots is in the liver and the another is in the CNS (the brain), but the depots in the CNS is difficult to be mobilized. The daily consumption of cobalamin in the body is 0.1% of the depots amount, so cobalamin deficient develops slowly and sneaking over many years. The Cobalamin, B12 has an enterohepatic circulation in the body, i.e. it is excreted by the bile and enters in the duodenum, where in the ileum is again absorb. In the tissues cells cobalamin has function as coenzyme. B12 deficiency can develop of different reasons. I am talking here about deficiencies as side effects/ complications of using Metformin. The cobalamin from the depot is not ****** out , but it is excreted trough the bile in the facet (****) i.e. it is not excreted by the kidney.
    The tablets I am using has the name: "Betolvex 1 mg, cyanocobalamin". Ask your doctor or pharmacist for side effect using this medication.
    PS About E-mailing you activate the envelope on the upper right corner and activate the green bottom. You will be guided for the remnant.
     
  13. Mars1946

    Mars1946 Type 2 · BANNED

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    Galja, the article is a story from 1930. I do not know nothing about American native food , I only republish this story from a volume " Biochemical, Physiological and Molecular aspects of Human Nutrition" from Elsevier, Saunders. For the moment I am waiting to receive a permission for the article to be published in this forum. As I can see, every time I use a medical word , I must have permissions from Who???.
    . In 1930, the medical persons find out the intake of to much protein, the result of that has been Ketonuri and loos of the Calcium from the body. On that time they have find that. If the same experiment is done now, the med. science will find much more negative thing about that.

    About your wish to explane about the consequences of the long term effects of hyperglycaemia, I must first to write it. This problem is the main reason for the diabetic complications, but no one of this doctors inform the patient. They talk to the patient as this persons are senile dement. Medical theoretical text are very simple, but the terminology is something unique. You must learn that from the beginning.
    I know who a doctors are , but many people think they are a members from the club of the gods. Ordinary physicians are not researcher, they are like me a persons who use the researcher results.

    I hope I get time to write that tomorrow. You hear from me.
    PS Have you find out how to send the private messages?




    Edited by Moderator to exclude assumptions about Moderators. OK
     
    #13 Mars1946, May 21, 2016 at 8:14 PM
    Last edited by a moderator: May 22, 2016
  14. Mars1946

    Mars1946 Type 2 · BANNED

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    Hi Galja
    Osteoporosis is divided in two type: Primary and second.
    The primary osteoporoses , of what Postmenopausal osteoporoses , because insufficient in the oestrogen , productions in the Ovaries and on account of age, the senile Osteoporosis.
    This two types are a big health problem in the society.
    Osteoporosis results in fracture frequency, where 20% are Hip-fracture.
    The treatment is : D-vitamin + fluoride + sufficient calcium supply, supply of oestrogen and treatment with bifosfonat.
    The second osteoporosis can be a result of treatment with Glucocoricoider , i.e. prednisolon, endocrine disorders, immobilisation and more.
    What do you mean : " HIGH DAIRY". Do you mean high carbs?

    PS About pemmican I believe to you, but the text is not mine, it is from the book.
     
  15. catherinecherub

    catherinecherub · Guest

    Hi @CDudley,
    You really need to see a Dr. to ask for blood test to reveal as to whether you are anaemic, have B12 deficiency or there is another reason as to why you are so tired.
    There are a small percentage of Metformin users who will experience low B12 levels and this article explains the symptoms and how it will be treated. It also discusses anaemia.
    http://www.nhs.uk/Conditions/Anaemia-vitamin-B12-and-folate-deficiency/Pages/Symptoms.aspx
     
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