If I miss a Metformin SR, I have to take a Loperamide otherwise my stomach speeds up and I get rear end probs ! I try very hard not to miss it, therefore.
Metformin does suppress appetite, it does help sensitise tissues insulin too. It also mimics the action of a protein called CBP and takes over the broken signalling between liver and pancreas. Plus, it was found recently to have a positive effect on brain cell repair and will be studied further for Alzheimer's. Added to those, a Cochrane review in 2014, found that people on Metformin had fewer cardiovascular events than on any other diabetes drug and even fewer cardiovascular events than those just using diet and exercise.
Additionally, it has been observed from patient records by Tayside Health Board, that compared to patients not taking it (non diabetics), 4% fewer people taking Metformin had cancer.Metformin has been seen in vitro to kill cancer cells.