The Doctor added Gliclazade 80mg twice a day to my existing regime of 2x100mg Metformin twice a day and Januvia 100mg once a day. i have been taking them for a week and have had some horrible side effects. Constipation (never been a problem) Chronic indigestion at night. I go to bed an hour later I am taking pills to relieve the heartburn, last night was so bad I got up and watched TV until it abated 2 hrs later. I have also been feeling sick, and have a constant uncomfortable feeling as though my food is not digesting properly. Is there any one out there who has had similar problems with this combination of drugs?