oo - ive not noticed any change in my nails yet (but only on my 2nd week of metformin (2 a day this week). Apart from the dodgy stomach at lunchtime, the very vivd dreams at night since taking my nighttime tablet, I have to admit im fairly impressed with its appetite suppressing activity. I dont think I have not felt hungry for several years - i was constantly thinking about what the next meal was. But since starting these tablets, I have really noticed a difference, and could quite easily not bother with dinner in the evenings - just have a light snack.