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Message: <blockquote data-quote="Freema" data-source="post: 1457505" data-attributes="member: 329519">There is a statistical connection to deficiency in vitamin B12 from people taking Metformin,but it is not all that devellops the deficiency, is that only a question of longterm results or is it individual / genetical differences in how much we uptake from food that a slowed or hindered by Metformin ?The problem there would then be that Metformin is actively preventing us from uptaking  the B12, in what way is not really know yet...Does it affect or damage the cells in the intestines that are the only ones that can uptake vitamin B12 or does it just block vitamin B12 uptake all over in the body.. ?Most people do eat enough vitamin B12, but Metformin interferes with the uptake in some people anyway... and maybe in all.Usually the level of vitamin B12 in the liver can be stretched out for up till 5-6 years... Maybe because this vitamin is so essential, our body has found a way to store it long term and only use is sparingly when in lack of outside adding,This maybe means that our body, I guess, then only use the vitamin B12 in the most essential places in the body, and it will for some take more than these 5-6 years before a deficiency can be seen in the blood samples.It is really worrying that Metformin interfere with uptake of vitmin B12, I still take my Metformin and also supplement of vitamin B12, but is this an insurance..? Maybe it could also be the way Metformin works in the liver that prvents the storing of vitamin B12 , who really know about that ?</blockquote>

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