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<blockquote data-quote="markd" data-source="post: 95285" data-attributes="member: 13859"><p>This is a very interesting study (quite a long read, however):</p><p></p><p><a href="http://care.diabetesjournals.org/content/29/11/2361.full" target="_blank">http://care.diabetesjournals.org/conten ... /2361.full</a></p><p></p><p>It looks at how Metformin works on diabetics of normal, overweight and obese build.</p><p></p><p>A couple of bits I found interesting:</p><p></p><p>></p><p>The fact that the two groups with lower weight performed better than their obese counterparts, irrespective of whether metformin or sulfonylurea treatment was used initially, suggests that the difference is probably a reflection of the impact of body weight on the disease process rather than a drug effect</p><p>></p><p></p><p>And </p><p></p><p>></p><p>Most interestingly, when the 27 metformin-treated patients with BMI <25 kg/m2 were examined, their median duration of successful monotherapy was longer at 7.0 years, compared with 6.4 years in their sulfonylurea-treated counterparts. Thus, there is evidence that metformin not only performs well in the nonobese individuals but might work even better in thin patients with type 2 diabetes. </p><p>></p><p></p><p>Mark.</p></blockquote><p></p>
[QUOTE="markd, post: 95285, member: 13859"] This is a very interesting study (quite a long read, however): [url=http://care.diabetesjournals.org/content/29/11/2361.full]http://care.diabetesjournals.org/conten ... /2361.full[/url] It looks at how Metformin works on diabetics of normal, overweight and obese build. A couple of bits I found interesting: > The fact that the two groups with lower weight performed better than their obese counterparts, irrespective of whether metformin or sulfonylurea treatment was used initially, suggests that the difference is probably a reflection of the impact of body weight on the disease process rather than a drug effect > And > Most interestingly, when the 27 metformin-treated patients with BMI <25 kg/m2 were examined, their median duration of successful monotherapy was longer at 7.0 years, compared with 6.4 years in their sulfonylurea-treated counterparts. Thus, there is evidence that metformin not only performs well in the nonobese individuals but might work even better in thin patients with type 2 diabetes. > Mark. [/QUOTE]
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