I have been on Metformin for 4 months and was always extremely tired, nausea, and dizziness. I took it upon myself to cut my dosage from 2 tablets a day to one in the morning and I have been off the extra tablet for over 8 days and feel a lot better. I have since informed my Dr. Has anyone else out there had severe reactions to Metformin?. Because of large dosage of Steroids,(Panafcortelone) I have difficulty in keeping my BSL under 8, but my steroids are been reduced on regular basis and I'm hoping for a good final result.