Hi candi-girl
The following is potentially going to cause see confusion :roll: :roll: but in a nut shell the jury is still out regarding whether
Levemir (Insulin Detemir) and
Humalog (Insulin Lispro) can be mixed together and injected.
Even health care professionals have been unable to come to an overall consensus on what to advise.
“If you are treated with
Levemir and another insulin/s you should
use a separate delivery device for each type of insulin injected.” (NovoNordisk 2005)
“
Levemir requires two injections a day but it
can be mixed in the same syringe with any of the rapid acting analogues.” (Walsh et al Using Insulin 2004 page 105)
With regard to the
pH -
Levemir pH 7.4 Humalog pH 7-7.8 therefore mixing it should make little difference.
Always draw up the rapid acting analogue first.
Some users have reported problems with the
Levemir slowing down the action of whatever it was mixed with.
The only insulin that is not advised for mixing with another insulin is
Lantus (Insulin Glargine) - pH 4 because of the different pH, and if you mix it with another insulin of a normal ph it will degrade faster.
There are several studies on mixing
Levemir with
Novorapid (Insulin Aspart)and interestingly the outcome was completely different in these two studies: :shock: :shock:
“Mixing
Levemir (Insulin Detemir) with
Novorapid (Insulin Aspart) resulted in a 40% reduction in the bioavailability and peak concentration of the latter agent.” Hussar 2006
“
Insulin detemir mixed with
aspart had equivalent effects on blood glucose versus giving them as separate injections." Nguyen 2010
Confusing isn’t it :?: :!: :roll: :roll:
As to how long does
Levemir last – that is really going to be determined by your own use of it and playing detective as to how long it lasts in you :!: :lol: :lol:
Duration: Up to 18 hours (Coopen 2007)
18-22 hours (Diabetes Daily)
10-14 hours (Medscape)
Peaking action is considered to be 3-9 hours (although peaking action is not pronounced).
Hope the above might help.
Best wishes
Txx
