Over time, we have heard a number of reports, yours among them, in which people have experienced change in mood fluctuations, behavior or personality, or overall mental-well being associated with statin use. In recent years, studies have reported an association of low cholesterol with irritability, violence, depression, aggression, suicide, and antisocial behavior. These have also been sometimes reported in individuals who take cholesterol lowering medication (statins). We previously published a paper describing effects in several individuals who experienced such side effects from statin use. We are also continuing to look into this problem, in the study in which you kindly participated.**
We are updating our data on people who have had behavioral problems on statins, who have agreed to be recontacted, so that we can focus in more detail on this issue.
In addition, our group is now collaborating with Dr. Cornelius Boerkoel from the University of British Columbia on a study to (1) learn more about the behavioral traits that are affected and (2) see whether people who develop these problems on cholesterol drugs are more likely to have certain genetic traits, traits that may heighten the risk associated with cholesterol reduction. That study is looking to do genetic and blood studies on 20 people who have had noteworthy mood/behavioral symptoms arising with statin use, in whom the problem improved when they were taken off statins. The study is especially interested in people in whom family members also experienced behavior or personality changes with statin treatment. When we speak with you, we will find out if you may be interested in learning more about participating in that study