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Neuropathy Garbage
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<blockquote data-quote="Antechinus" data-source="post: 1945948" data-attributes="member: 493842"><p>I think neuropathy is a little more complex than just damage to the capillaries that feed the nerve. Causes of neuropathy are not well understood but there is connection to high blood sugars and length of diabetes (glycosilation would be the main cause here); genetics plays a big part and there are many people without diabetes that have neuropathy; Vit B and or Vit D deficiency can lead to it; alcohol is another cause, Hi BMI another factor, and smoking (which really does stuff up the peripheral arteries like diabetes does). Also there are 5 different nerve types, based on diameter, and all, or only one, can be effected with neuropathy. Usually it is the smaller fibres that are affected first, and these can be very painful. These are pressure and temperature sensing nerves, and often worse at night due to nightly fluid retention. Sometimes it is the sensory part of the nerve that is effected, whether by glucose or vascular restriction such as in diabetic dermopathy. </p><p>There is some complex chemical pathways within nerve fibers that are interfered with by glucose and this can lead to nerve fiber damage as well. </p><p>Also nerves become super sensitive when they are being damaged and when healing. There is a threshold where nerves are painful while being damaged, and then become numb as the damage stops conduction. As the nerves regenerate and fall back below the pain threshold the pain comes back in, until they are healed enough to conduct properly again. Healing nerves are sensitive.</p><p>Things to do help are get your VIT C, B &D checked as these all effect nerve health, give up the booze and control blood sugars.</p><p>Smoking is dumb at any time, but smoking with diabetes is seriously stupid.</p><p>Some people believe that small fiber neuropathy begins during the prediabetes phase of the disease and so when a person finally diagnosed with diabetes significant damage has already begun. So early intervention is really important, its just getting doctors and DN's to understand the need for early assessment and care.</p><p>I'm still learning about peripheral neuropathy, it's a really complex area of medicine.</p></blockquote><p></p>
[QUOTE="Antechinus, post: 1945948, member: 493842"] I think neuropathy is a little more complex than just damage to the capillaries that feed the nerve. Causes of neuropathy are not well understood but there is connection to high blood sugars and length of diabetes (glycosilation would be the main cause here); genetics plays a big part and there are many people without diabetes that have neuropathy; Vit B and or Vit D deficiency can lead to it; alcohol is another cause, Hi BMI another factor, and smoking (which really does stuff up the peripheral arteries like diabetes does). Also there are 5 different nerve types, based on diameter, and all, or only one, can be effected with neuropathy. Usually it is the smaller fibres that are affected first, and these can be very painful. These are pressure and temperature sensing nerves, and often worse at night due to nightly fluid retention. Sometimes it is the sensory part of the nerve that is effected, whether by glucose or vascular restriction such as in diabetic dermopathy. There is some complex chemical pathways within nerve fibers that are interfered with by glucose and this can lead to nerve fiber damage as well. Also nerves become super sensitive when they are being damaged and when healing. There is a threshold where nerves are painful while being damaged, and then become numb as the damage stops conduction. As the nerves regenerate and fall back below the pain threshold the pain comes back in, until they are healed enough to conduct properly again. Healing nerves are sensitive. Things to do help are get your VIT C, B &D checked as these all effect nerve health, give up the booze and control blood sugars. Smoking is dumb at any time, but smoking with diabetes is seriously stupid. Some people believe that small fiber neuropathy begins during the prediabetes phase of the disease and so when a person finally diagnosed with diabetes significant damage has already begun. So early intervention is really important, its just getting doctors and DN's to understand the need for early assessment and care. I'm still learning about peripheral neuropathy, it's a really complex area of medicine. [/QUOTE]
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