This is only true for drugs that increase the bodies production of insulin. A lot of newer drugs along with Maraformin do not increase insulin levels.
You also need to define "worsening", for example, high does of insulin can stop you going blind and losing your legs, but do increase the risk of heart attaches and strokes. Personally, if I was forced to choose, I would choose not to go blind. (But with low carb diet I don't have to make that choice at present.)