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Psoriasis And T2

Janya

Janya

Member
Messages
12
Type of diabetes
Type 2
Treatment type
Tablets (oral)
Hey people! I'm looking for any info out there pls!

Does anyone know anything about a link between T2 and psoriasis?

I've had psoriasis since my early 20's (I'm 47 now), then started with symptoms of shakes, exhaustion (Insert any T2 symptom here!) a few years later. Got a dx of Fybromyalgia quite a few years after that after many consultant appointments and MRI scans etc. Just 2 weeks ago I was dx'd with T2 diabetes with a cheery comment of 'oh, I see you have had a few high glucose readings in the past' (smh...thanks for telling me at the time pal). I was also called in on a weekly basis during the last 2 months of my last pregnancy to check glucose levels as they were high, but told that was normal and just a pregnancy issue that would pas once baby was born. Baby is now 16 and just got fantastic A grades in his GCSE's! Sorry OT, but proud Mummy mo there! Actually, not so OT as I am very worried that he has inherited my ****** T2/psoriasis/blagh genes.

My paternal Grandmother and biological father had/have T2 and psoriasis, so has his sister and her daughter and my 1/2 brother.(have only just found this out as I don't actually know them so well!)

I'm now reading about auto-immune dysfunctions related to psoriasis which run hand in hand with insulin resistance, heart disease, stroke and T2 diabetes.
I have cut carbs in our diets and exercise what I can (but blood sugars drop dramatically whenever I move and exercise...I fall over in a heap of incoherent blagh)

Doc has not been very helpful in a 'take these 2 Metformin a day and don't have sugar in your tea, see you in a month' kinda way. I'm feeling more than a tad miffed and peed off that I've just spent the last 20 years of my life with some kinda insulin resistance, psoriasis linked ****** blood sugar thingy mis dx'd as FMS (Ok, rant over!)

Does anyone know any further info or research about the link, how to manage both psoriasis and T2 and more important, what I should be looking out for in my son.

Thanks for any info
d~x
 
Hi, I have severe psoriasis and psoriatic arthritis as well as T2 and a few other autoimmune goodies. I have been told that people with psoriasis are much more likely to develop T2 but not until after I had it :***: I have also been told that my excess weight is aggravating the psoriasis. GRRRR. I have come to the understanding that in my late teens I started to become more insulin resistant, this was quickly followed by 2 pregnancies and psoriasis popping up on my face of all places shortly into my first pregnancy. I passed the short glucose tolerance test with both pregnancy so the fact that my skin got worse, my weight kept climbing, and arthritis developed never caused anyone to think to check my sugars. I was just fat and lazy right? I think if I had been told almost 30 years ago that these things were connected and a low carb diet would help I would be much healthier now. I can not point you to any particular study but please google it and let me know what you come up with. I think for your son( both of my boys are overweight and one is hypoglycemic with psoriasis and the other with the arthritis) that getting him into a lifelong pattern of low carb with the knowledge of why he needs to stay on it, will save him a lot of grief later in life. I don't know if this helps and it is just my feelings on the matter. I am not a doctor. Welcome to the forum.
 
Seem like psoriasis and diabetes (both Type 1 and Type 2) tend to cluster together. Dr Richard Bernstein said he sees psoriatic nails in just about every diabetic patient he has.
 
Just adding, I've been doing quite a bit of research into my own genetics lately and the MTHFR mutation and fibromyalgia are often linked (this mutation affects ability to process folate). My mother was a psoriasis sufferer and I have the HLA-B27 status that predisposes to psoriasis, but luckily haven't developed it.

I've found the genetics testing very interesting, however, I would say that if anyone suffers from health anxiety, having it done could be a double-edge sword and may create other issues.
 
Indy51 said:
Seem like psoriasis and diabetes (both Type 1 and Type 2) tend to cluster together. Dr Richard Bernstein said he sees psoriatic nails in just about every diabetic patient he has.
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I did not know this. I did know that psoriatic nails is a strong indicator for psoriatic arthritis. I certainly have nail involvement on both hands and feet.
 
Do you know what triggers your psoriasis? With me, it is milk proteins and the preservatives in things like bacon, chorizo and ham.

When I went very low carb for the T2, I ended up having worse psoriasis because of the increased dairy and cold meats.
But I have sorted it now.
So long as I avoid the dairy with whey in it (and stick to wheyless things like hard cheese, double cream and butter) I am OK. Oh the hardship.
And I can tolerate one or two portions of preserved meats a week. Any more and I flare up.

So it has turned out to be quite workable, but I do wonder how many people are out there who don't realise that psoriasis is often diet related, and who suffer endlessly and needlessly... Doctors are pretty gaumless on dietary links to things.
 
I have never been able to find a specific dietary culprit. My psoriasis is severe and crippling when flared. I have been on immune modifying biologics for over 10 years now. Methotrexate, cyclosporin, amevive, humira, embrel, remicade, and now stelara which is the best of the bunch. I lost access to my stelara for 6 months due to BS and paperwork snafus and when my Derm saw my skin he freaked. I had a PASI score of 90 out of 100 for severity and I looked and felt like I had second degree burns on about 80% of my body, not fun. I have been back on the stelara now for 3 weeks and the improvement is nothing short of a miracle. During that 6 month period when my immune system was let out to play , my previously easy to control D went right off the rails with an A1c of 10.5 and is refusing to be tamed easily, even with meds and low carb. I also have a multinodular goiter that was investigated and biopsied 3 years ago and has not bothered me since. Now my thyroid is swollen and I need to start that ultrasound and biopsy merry-go-round again. I firmly believe that the psoriasis, the arthritis, the thyroid issues, and the D are all immune related along with my asthma, allergies, blepharitis, and rosacea. But all that being said, I look fine and should get my backside back to work or so I have been told. Sorry to rant but it gets soooo frustrating. I am glad you can control it with diet. I wish I could.
 
@chalup - did you watch the Dr Alessio Fasano video I posted a while ago on the aetiology of autoimmune diseases? Even if you have no direct reaction to wheat/gluten that you can pinpoint, it can trigger the intestinal permeability that allows foreign molecules access to the blood stream. As long as you are eating gluten, you are likely to have intestinal permeability. Other factors can be involved, but it is considered to be the major insult given how widespread wheat is in the Western diet.

In case you didn't see it, here is the video:

 
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I have been VLC and wheat/gluten free for a very long time. The better part of 11 years with a bit of time off for bad behavior. I will check it out but not tonight as it is 3 am here and finally cooling off enough to sleep. 30C today and I do not do heat well. Thanks for the link.
 
chalup said:
I have been VLC and wheat/gluten free for a very long time. The better part of 11 years with a bit of time off for bad behavior. I will check it out but not tonight as it is 3 am here and finally cooling off enough to sleep. 30C today and I do not do heat well. Thanks for the link.
Click to expand...
With your various conditions, genetic testing might be a good avenue for you to check out. From memory, the MTHFR mutation is very common and can interact with drugs - I think methotrexate is one of them. There are also SNPs that can cause some drugs to be ineffective, take longer to metabolise and so forth. The fact that you already have autoimmune conditions means you have genetic predispositions. Having more information may help with treatment options. Just a thought.
 
I had psoriasis from the age of 6 but when I went through early menopause in my 40s it started to disappear and now at 69 years old there is not a sign of it.
I am having trouble with my thyroid at present so Mr.Google has been very helpful.
It seems D2, thyroid, psoriasis, Reynards, early menopause (which I had or have) are all auto-immune linked so I don't stand a chance.
 
Indy51 said:
With your various conditions, genetic testing might be a good avenue for you to check out. From memory, the MTHFR mutation is very common and can interact with drugs - I think methotrexate is one of them. There are also SNPs that can cause some drugs to be ineffective, take longer to metabolise and so forth. The fact that you already have autoimmune conditions means you have genetic predispositions. Having more information may help with treatment options. Just a thought.
Click to expand...
HMMMM, I wonder if that is why taking folic acid to stop the stomach side effects of methotrexate never worked for me. I would love to have the genetic testing done but I cannot afford it. Methotrexate has been a constant in my life for about 20 years and I have stopped taking it only when on cyclosporin, and just in the last couple months. I do not believe it is doing anything for me as my recent flare demonstrated and it is a liver toxin, a big bad one. Where did you get this testing done?
 
carol43 said:
I had psoriasis from the age of 6 but when I went through early menopause in my 40s it started to disappear and now at 69 years old there is not a sign of it.
I am having trouble with my thyroid at present so Mr.Google has been very helpful.
It seems D2, thyroid, psoriasis, Reynards, early menopause (which I had or have) are all auto-immune linked so I don't stand a chance.
Click to expand...
Kind of how I feel. I hit menopause at 37. No way of knowing if it was the medications, autoimmune, or just genetics.
 
I got my test done at blue horizon medicals. Finger prick to fill a small vial, I had Thyroid Check plus Eleven cost £99.00 Speedy reply by e-mail. Result showed that I have very high anti-bodies, high T4 Total and Free T4, high Serum Folate. I am deficient in B12 & D. Have booked an appointment with Doctor on 2nd September, should be an interesting discussion.
 
I am in Canada and currently waiting to get in to see an endo. Also waiting for an ultrasound of my thyroid as it has suddenly gotten very swollen. 3 years ago I had ultrasound and biopsy and was declared benign multinodular goiter. I do believe it is affecting my BG and weight loss despite the normal TSH tests. Something is going on in there.
 
Thanks for all of the replies and insight. I'm reading through all the info :)
 
chalup said:
HMMMM, I wonder if that is why taking folic acid to stop the stomach side effects of methotrexate never worked for me. I would love to have the genetic testing done but I cannot afford it. Methotrexate has been a constant in my life for about 20 years and I have stopped taking it only when on cyclosporin, and just in the last couple months. I do not believe it is doing anything for me as my recent flare demonstrated and it is a liver toxin, a big bad one. Where did you get this testing done?
Click to expand...
Apparently the body doesn't process folic acid very well - takes about 5 more steps and if you have the MTHFR variant, the conversion is even worse. The supplement to take is apparently folinic acid or a methyl version - in fact, it's best to take the methylated versions of B vitamins like methylcobalamin version of B12 etc. I buy a methyl version B Complex from Thorne Research. It would be worthwhile you watching some of the Ben Lynch videos on Youtube. I'll see if I can track the one I was watching on the subject and post it for you.

I had the testing done via Ancestry.com - they give you an Ancestry report and you can then download the raw data and run it through a DNA report services called Promethease. Or you can use a similar service called 23andme.com.

Will post the video when I find it :)
 
This is one of the videos - I picked this one because it's specifically about the interaction between the MTHFR mutation and the thyroid:

 
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