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Q for long term Metformin users

H

hanadr

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I've been on Metformin now for nearly 10 years. Initially,I was put on 3 x 500mg per day with Gliclazide too, but I went low carb and now use 2 x 500mg. 1 night and 1 morning. Every now and again, I've not had the nighttime dose. I've forgotten and gone to bed very late. It doesn't seem to have much effect on my fasting BG next morning. I certainly have no tummy upset symptoms and my weight loss nowadays is a desperate struggle.
It struck me I might have adapted so well to it that my metabolism hardly notices it.
Hana
Ps I aim for fasting Bg of below 5 and bedtime Bg of around or just below 5. I achieve it most days.
 
hanadr said:
I've been on Metformin now for nearly 10 years. Initially,I was put on 3 x 500mg per day with Gliclazide too, but I went low carb and now use 2 x 500mg. 1 night and 1 morning. Every now and again, I've not had the nighttime dose. I've forgotten and gone to bed very late. It doesn't seem to have much effect on my fasting BG next morning. I certainly have no tummy upset symptoms and my weight loss nowadays is a desperate struggle.
It struck me I might have adapted so well to it that my metabolism hardly notices it.
Hana
Ps I aim for fasting Bg of below 5 and bedtime Bg of around or just below 5. I achieve it most days.
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Hana I have just seen this hread after asking you about your metformin use on another thread. I was referring o a post a few days ago in which you said you sometimes ook metformin every other day. I think you have answered nmy question here . Obviously the answer is hat you smetimes forget to take it at night.!
 
Hi Hana. I have often wondered the same thing myself as I have been on Met for eleven years now. Never had any of the side effects either! I was on Met plus 80mg of glic (twice a day) until Christmas when GP cut the glic to 40mg twice a day.
So, as you say, just how much does the Met add to my D. armoury. I'm quite happy taking it (not least because of the other beneficial effects) but what is it is doing for my D.
 
Hi Hana,

I'm not a long term Metformin user but as a Type 1 I could certainly see the changes that it made to my insulin requirements.

I started taking Metformin around January 2011 and for the first 6 months my insulin requirements dropped noticeably; both the bolus (short acting) and basal (long acting). My weight also dropped considerably (and by the way I made no other lifestyle changes; i.e diet was the same, and I actually stopped going running; but still the weight came off - so much for the move more do less view...).

Anyway, I have noticed that now my insulin requirements have risen slightly and the weight loss has stalled. I think one of the great things about Metformin is that it seems to have got rid of the dawn phenomenon for me which is great; now I wake up with what I go to bed at so overnight control is much easier. I'm still a unit or 2 down in terms of basal and I'd say maybe on average 1 unit down on bolus; so there is a slight improvement in insulin sensitivity but I would firmly agree that the effectiveness of the drug has declined over the last year. The most noticeable and measurable improvement was for the initial 6 months.

I'm on 2x 500 mg morning and night.

Best

Dillinger
 
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