Readings stubbornly high overnight, advice/ideas needed

[mariavontrapp]

Hi, I have managed my diabetes successfully for 8 years through low-carbing, but I had a sudden big rise in HbA1c a few weeks ago and was put on Glimepiride, titrating up to 3mg.
At first I took the tablets with breakfast, but was getting hypos before lunch and highs overnight, so then I was advised to take them with my evening meal instead.

My problem is, no matter what I do, my glucose goes up to about 11 mmol at 9pm and then sits there all night until about 10am the next day.
If I wake in the night I check it and it is still around 11mmol. There doesn't seem to be any dawn phenomenon going on. So that's over 12 hours of high glucose every day.

It's as if my pancreas is hibernating over night. The tablets don't seem to work until mid-morning, no matter what time I take them.

Can anyone shed any light on this?

 

[chrisjohnh]

Hi, I have managed my diabetes successfully for 8 years through low-carbing, but I had a sudden big rise in HbA1c a few weeks ago and was put on Glimepiride, titrating up to 3mg.
At first I took the tablets with breakfast, but was getting hypos before lunch and highs overnight, so then I was advised to take them with my evening meal instead.

My problem is, no matter what I do, my glucose goes up to about 11 mmol at 9pm and then sits there all night until about 10am the next day.
If I wake in the night I check it and it is still around 11mmol. There doesn't seem to be any dawn phenomenon going on. So that's over 12 hours of high glucose every day.

It's as if my pancreas is hibernating over night. The tablets don't seem to work until mid-morning, no matter what time I take them.

Can anyone shed any light on this?

I think a sudden change like this deserves some clinical investigation. I wonder whether another possible explanation could be the reaching of some kind of tipping point in insulin resistance. If further weight loss appears not feasible then perhaps exercise like resistance training might help to get that A1c down? But you may well have already considered this.

 

[mariavontrapp]

I think a sudden change like this deserves some clinical investigation. I wonder whether another possible explanation could be the reaching of some kind of tipping point in insulin resistance. If further weight loss appears not feasible then perhaps exercise like resistance training might help to get that A1c down? But you may well have already considered this.

I'm awaiting the results of a scan, but the nurse seems resistant to any blood tests at the moment. I think I'm beginning to baffle her

 

[HSSS]

I'm awaiting the results of a scan, but the nurse seems resistant to any blood tests at the moment. I think I'm beginning to baffle her

Well doing tests might unbaffle her then.
Any illnesses/change in lifestyle/food/stress/medication in the months the preceeding that hba1c ?

 

[mariavontrapp]

Well doing tests might unbaffle her then.
Any illnesses/change in lifestyle/food/stress/medication in the months the preceeding that hba1c ?

Everything was ok over the summer, felt well in September.
Covid moderna vaccination on October 2nd, bloods tested 6 weeks later and HbA1c was 107. There has been no logic to anything since then, but all the nurse will talk about is increasing my medication. I just can't see how to bring down the night time readings and I don't feel in control of the situation.

 

[chrisjohnh]

Everything was ok over the summer, felt well in September.
Covid moderna vaccination on October 2nd, bloods tested 6 weeks later and HbA1c was 107. There has been no logic to anything since then, but all the nurse will talk about is increasing my medication. I just can't see how to bring down the night time readings and I don't feel in control of the situation.

There have been reported instances of vaccine-induced hyperglycaemia and some it seems lasting up to a month. Does seem a little coincidental timing in your case but then again could be irrelevant.

 

[mariavontrapp]

There have been reported instances of vaccine-induced hyperglycaemia and some it seems lasting up to a month. Does seem a little coincidental timing in your case but then again could be irrelevant.

I have been thinking along these lines. I did have a massive immune reaction at the time and I also got tinnitus and significant hearing loss, which is resolving itself. I just can't seem to make sense of my glucose levels, they are all over the place

 

[chrisjohnh]

I have been thinking along these lines. I did have a massive immune reaction at the time and I also got tinnitus and significant hearing loss, which is resolving itself. I just can't seem to make sense of my glucose levels, they are all over the place

I hope the medics will be able to explain and fix the problem, or confirm that in time it will self-resolve.