The Insight is smaller than the Combo and weighs less. The insight manages multi bolus's which the combo cannot. The insight remembers the dose and bolus settings when you need to change a cartridge, battery, infusion set, the combo does not and you need to reset any bolus's.
The Insight handset is bit slower but it has to deal with working out multiple bolus's - I have got used to its speed.
The Insight is not bubble free, I do need to check once a day, normally in morning.
The Insight is much easier to operate via the handset or pump.
Others have posted issues with both pump and handset - it appears to me that the USB charging is not robust and if you plug it into a charger that is too powerful it causes it to report an error.
For me the Insight Pump battery lasts over a month, the handset about a week.