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Results using Saxagliptin

J

Jimob23

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Was diagnosed with Type 2 about 2.5 years ago .
Along with diet /excercise was put on 2x 500g metaformin daily .
This was then increased to 2 x 500 twice daily about 8 months ago .
I have been able to test on a rugular basis and noticed that recently even after fasting my levels were always in the region 6.5 to 8.5
At my latest 6 monthly check up about 2 weeks ago I was put onto 5mg Saxagliptin per day along with the existing metaformin
Am taking the Saxagliptin before first meal of the day but am still getting readings in region of 7.5 in the early morning before taking the Saxagliptin and even during the day nothing under 6.5 . :(
Was wondering if it still has to 'kick in' and other peoples experiances
Thanks Jim :?
 
Hi

Sorry didn't want your post to go unanswered. I had never heard of Saxagliptin and couldn't really find out much on-line.

I would suggest phoning your Dr's surgery and asking to speak to your Dr. Our surgery does "phone" consultations, so hopefully yours does too.

Karen
 
Jimob,
I don't have any knowledge of your medication, but I do know that if your BGs are too high for your target, you can use diet to get them down. Reducing your carbs should work and there's lots of info on controlling carbs on this site.
Hana
 
Hi. Saxagliptin is one of a group of gliptins (Google Gliptins); I'm on Sitagliptin. They are at their best suppressing spikes as they suppress an enzyme (DPP-4) that in turn supresses insulin production after a certain time following a meal hence insulin production is extended. In general they have less and less effect as your blood sugar approaches normal so they can't produce hypos. Your blood sugar, although higher than a good target, is not too bad hence I suspect the drugs effect on you is limited other than when you eat excess carbs. I would recommend testing 2 hours after a main meal not in the mornings as your morning reading is influenced by liver dumps during night and doesn't tell you that much.
 
Thanks Daibell

I forget the name of the alternative talked about but like you said it did seem as if the selected one was the most user friendy .
Will go with your testing suggestion and see how things progress ,hopefully better :)
I see you are on 100 mg where I am on 5mg .Do I then understand it correctly that like with the Metformin there is the option to increase mg ,by doc, as and if required ?
lastly do you take your 100mg in morning or evening .I only ask as like you am on Simvastatin where only by chance did I discover they are best taken at night :oops:
Thanks in advance Jim
 
Hi Jimjob. For Sitagliptin there is really only one dose level of 100mg and I think it's once a day in the evening on my prescription which is when I take it together with the Simvastatin. I suspect Saxgliptin has the different doseage level you are having. I'm sure if you Google it or look at the leaflet you have it will indicate whether other doseage levels can be prescribed. If you see levels below 8.5 on your meter 2 hours after a typical meal then I wouldn't worry too much but a bit lower would be the target to go for. Your annual HBa1c should be a good guide and I would be aiming for below 7, preferably below 6.5, which I currently fail!
 
Thanks again Daibell

Must admit I followed the general mode of diet ,exercise etc and let the Metformin do its work without looking into the why's and wherefore's .
Came as a bit of a shock when the levels went wrong and they started me on the Saxgliptin so started doing some research and found this site .
Have a friend who eventually lost a leg due to type 2 not controlled so got a wake up call .
Was aware of the early morning dump issue and have never really understood as to why the requirement to have a fasting blood test if this situation may occur
Any simple answer ?
Cheers Jim
 
Hi. Interesting question the fasting blood test thing. I discussed this with another T2 a while back and we both agreed there appeared to be little point. I think HCPs use it for diagnosis because it's simpler than the GTT (Glucose Tolerance Test) but not as reliable and it then transforms into a habit. The HBa1C is generally recognised as a fairly good test and when used supercedes the fasting test. I suspect many GPs don't really consider the impact of the liver dump. One of the hosiptal phlebotomists once said to me during blood giving that the fasting period was quite critical and that 14 hours was too long and should be around 12 max probably due to the liver dumping. If anyone reading this knows of positive reasons to do the fasting test, I'd be interested in learning something; maybe it just falls out of the cholesterol test for free?? I must do a search for more info myself.
 
Once again thanks for response
It does fall into line to what I was thinking
Not knocking my diabetes nurse at all but posed the same question to her where it was passed over as if that is the procedure and lets move to the levels issue :)
Someone may come along with the answer shortly
 
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