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Review highlights insulin resistance, not cholesterol, in predicting type 2 diabetes

DCUK NewsBot

DCUK NewsBot

Well-Known Member
A new review has challenged the importance of cholesterol in predicting type 2 diabetes and cardiovascular disease, arguing that insulin resistance is the most important predictor. The review, which appears in The Pharmaceutical Journal, also questions the value of the cholesterol-lowering drug statins, suggesting the benefits have been "grossly exaggerated". The researchers - Drs Maryanne Demasi, Robert H Lustig and Aseem Malhotra - highlight a number of studies where the directive to lower cholesterol using statins has failed to improve health outcomes. "'Big Pharma' has certainly triumphed, yet the patients have not," they wrote. "Given that statins can give the illusion of CVD protection, predispose the development of type 2 diabetes in up to 1 in 50 patients taking these drugs, and cause reversible side effects in up to 29% of users, stopping statins may paradoxically 'save more lives' and improve quality of life in those taking them." The researchers also target the need for current thinking about obesity and the role of calories to change. Instead of the amount of calories being significant, the focus should actually be on the sources of calories consumed. "Calorie-focused thinking is inherently biased against high-fat foods, many of which appear to be protective against obesity and the diseases of metabolic syndrome, and supportive of refined starch and sugar replacements, which are clearly detrimental, and exclusive of their calories and effects on weight gain." They say shifting this message could be achieved through reinforcing overeating and inactivity as the underlying causes of type 2 diabetes and CVD, rather than focus simply on calorie counting. They also propose insulin resistance is the most important predictor of CVD and type 2 diabetes. "The risk factor that has been most consistently associated with CVD, type 2 diabetes and obesity is 'insulin resistance' [which] plays a primary and causative role in the pathogenesis of hypertension, dyslipidaemia, fatty liver disease, and type 2 diabetes, collectively termed 'metabolic syndrome'." To lower insulin resistance the researchers advocate eating a high-fat, low-GL (glycemic load) diet and to get regular exercise. Then, instead of providing drug companies with greater financing, healthcare funds can be spent implementing better policies for lowering type 2 diabetes rates. "Then, and only then, might we achieve the goal of attenuating the prevalence of CVD and the other chronic diseases of the metabolic syndrome," the authors concluded.

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DCUK NewsBot said:
A new review has challenged the importance of cholesterol in predicting type 2 diabetes and cardiovascular disease, arguing that insulin resistance is the most important predictor. The review, which appears in The Pharmaceutical Journal, also questions the value of the cholesterol-lowering drug statins, suggesting the benefits have been "grossly exaggerated". The researchers - Drs Maryanne Demasi, Robert H Lustig and Aseem Malhotra - highlight a number of studies where the directive to lower cholesterol using statins has failed to improve health outcomes. "'Big Pharma' has certainly triumphed, yet the patients have not," they wrote. "Given that statins can give the illusion of CVD protection, predispose the development of type 2 diabetes in up to 1 in 50 patients taking these drugs, and cause reversible side effects in up to 29% of users, stopping statins may paradoxically 'save more lives' and improve quality of life in those taking them." The researchers also target the need for current thinking about obesity and the role of calories to change. Instead of the amount of calories being significant, the focus should actually be on the sources of calories consumed. "Calorie-focused thinking is inherently biased against high-fat foods, many of which appear to be protective against obesity and the diseases of metabolic syndrome, and supportive of refined starch and sugar replacements, which are clearly detrimental, and exclusive of their calories and effects on weight gain." They say shifting this message could be achieved through reinforcing overeating and inactivity as the underlying causes of type 2 diabetes and CVD, rather than focus simply on calorie counting. They also propose insulin resistance is the most important predictor of CVD and type 2 diabetes. "The risk factor that has been most consistently associated with CVD, type 2 diabetes and obesity is 'insulin resistance' [which] plays a primary and causative role in the pathogenesis of hypertension, dyslipidaemia, fatty liver disease, and type 2 diabetes, collectively termed 'metabolic syndrome'." To lower insulin resistance the researchers advocate eating a high-fat, low-GL (glycemic load) diet and to get regular exercise. Then, instead of providing drug companies with greater financing, healthcare funds can be spent implementing better policies for lowering type 2 diabetes rates. "Then, and only then, might we achieve the goal of attenuating the prevalence of CVD and the other chronic diseases of the metabolic syndrome," the authors concluded.

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"Drs Maryanne Demasi, Robert H Lustig and Aseem Malhotra."
Names I hold in high esteem. Leading the fight against outdated yet still established medical opinion.
Geoff
 
librarising said:
"Drs Maryanne Demasi, Robert H Lustig and Aseem Malhotra."
Names I hold in high esteem. Leading the fight against outdated yet still established medical opinion.
Geoff
Click to expand...
Whilst I happen to agree with you here, and support the message they put forward, nevetheless I am aware that these guys and gals are trailblazers, and so are expressing a somewhat biased viewpoint in opposition to the bias seen in mainstream health science. This is an inevitable consequence of holding what is currently a minority viewpoint,and whilst there is a growing database of studies and experiences to support this (my own included) readers here must be mindful of this when they post the article onward. I personally try not to hold up any guru's as being the fount of all wisdom and knowledge

I recognise the authors but refuse to put them on a pedetal. I have seen this effect happpen too often with other lifestyle changers where followers quote their favourite guru with almost religious zeal, and we need to keep an active inquisitive mind ourselves. But it is certainly the consensus outside this Forum that a LC, high fat diet has a minority following and many think it is a dangerous or harmful way of living.

We await further research that will provide the irrefutable evidence that shows it is sustainable long term and safe for most. Early days still. Hopefully these guys will be able to provide this evidence
 
Malhotra Aseem is amazing.

Insulin resistance etc is also being linked to cancer..see Professor Robert Thomas. He got a youtube video going back to 2014....

Just been to a talk by him and insulin and diabetes was consistently mentioned as drivers to cancer.
 
donnellysdogs said:
Malhotra Aseem is amazing.

Insulin resistance etc is also being linked to cancer..see Professor Robert Thomas. He got a youtube video going back to 2014....

Just been to a talk by him and insulin and diabetes was consistently mentioned as drivers to cancer.
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My son recently had cancer. A so called Guru who is running a successful MLM operation declares that the problem is due to an acid diet, and that he must change immediately to an alkali diet. The mainstay of the diet plan is for my son to eat crushed apricot kernals, , which research will tell us contain cyanide, and are toxic. Luckily I was able to intervene in time. My wife unfortunately thinks this Guru has the sun shining from his derriere, and has a kind face, and so she is still pushing almond kernel diet to anyone she meets with cancer,

So yes, I do not find gutu's with a youtube presence to be any better than my neighbour as far as advice is concerned. At least the doctors authoring this article have a reliable track record, but IMO the jury is still debating their message about IR being behind T2 (and now cancer?)
 
Oldvatr said:
My son recently had cancer. A so called Guru who is running a successful MLM operation declares that the problem is due to an acid diet, and that he must change immediately to an alkali diet. The mainstay of the diet plan is for my son to eat crushed apricot kernals, , which research will tell us contain cyanide, and are toxic. Luckily I was able to intervene in time. My wife unfortunately thinks this Guru has the sun shining from his derriere, and has a kind face, and so she is still pushing almond kernel diet to anyone she meets with cancer,

So yes, I do not find gutu's with a youtube presence to be any better than my neighbour as far as advice is concerned. At least the doctors authoring this article have a reliable track record, but IMO the jury is still debating their message about IR being behind T2 (and now cancer?)
Click to expand...

Both Aseem and Prof Thomas thankfullly do not recommend such cyanide!!

Straightforward yogurt, berries, nuts, broccoli, turmeric.

I 100% believe in turmeric. I think this stopped my 2nd boob from going completely bad with cancer and only found abnormal cells when it was removed.

Turmeric was only difference in hubby n me when he got an awful airborne virus and 1st time ever in 50 years off sick. I had low everything in blood and he never drank or had turmeric. I did. I didnt get hus virus.

Changes in my diet although small have completely reversed GERD too. My excellent gastro chap recommended no tomatoes or onions at all in any food ie not eat soup as the basis of that is onion. Add in oregano oil tablet for good bacteria and my SIBO test only showed good results too.

Some advice from docs does have to be checked but some has been superb for me.
 
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