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Semiglutide trial Ascend

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daisydoole

Newbie
Messages
4
Type of diabetes
Type 2
Treatment type
Tablets (oral)
I started my trial 10.10.25, side affects not too bad. In the first 3 months I lost 14 pounds but more importantly my fasting glucose level came down to in the 5s so very glad. However 26 days ago I started the full trial. Weight loss stopped almost immediately and my fasting glucose level has gone up to 8.8 today. So i guess I am on the placebo. My food noise is back too. I will give it another month and see if this changes, but my health is more important than this trial and I will remove myself from it if needed.

Anyone else have comments on the full trial, most of the comments I see are about the run-in.
 
Hi @daisydoole & welcome to the forum
Don’t know if you’ve seen this thread on the ascendplus trial

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Thread 'Anyone on the Ascend Plus trial?'

Just thought aid start a discussion here for anyone on the Ascend Plus trial by Oxford University.

Started my “Run In” phase yesterday and so far so good. No side affects other than fatigue. How are other folks doing?
 
daisydoole said:
I started my trial 10.10.25, side affects not too bad. In the first 3 months I lost 14 pounds but more importantly my fasting glucose level came down to in the 5s so very glad. However 26 days ago I started the full trial. Weight loss stopped almost immediately and my fasting glucose level has gone up to 8.8 today. So i guess I am on the placebo. My food noise is back too. I will give it another month and see if this changes, but my health is more important than this trial and I will remove myself from it if needed.

Anyone else have comments on the full trial, most of the comments I see are about the run-in.
Click to expand...
I realised I was on the placebo, and decided to withdraw from the trial and my GP practice agreed to prescribe the Rybelsus for me after seeing the effect the semaglutide had on my BG and other issues. I would recommend talking to your GP surgery about this and seeing if they can do anything for you.

There are a lot of posts from people at various stages of the run in and trial over on the Ascend Plus thread mentioned above, so you will be able to find out more from people who think they are the real stuff.
 
AllieRainbow said:
I realised I was on the placebo, and decided to withdraw from the trial and my GP practice agreed to prescribe the Rybelsus for me after seeing the effect the semaglutide had on my BG and other issues. I would recommend talking to your GP surgery about this and seeing if they can do anything for you.

There are a lot of posts from people at various stages of the run in and trial over on the Ascend Plus thread mentioned above, so you will be able to find out more from people who think they are the real stuff.
Click to expand...
Thank you will do
AllieRainbow said:
I realised I was on the placebo, and decided to withdraw from the trial and my GP practice agreed to prescribe the Rybelsus for me after seeing the effect the semaglutide had on my BG and other issues. I would recommend talking to your GP surgery about this and seeing if they can do anything for you.

There are a lot of posts from people at various stages of the run in and trial over on the Ascend Plus thread mentioned above, so you will be able to find out more from people who think they are the real stuff.
Click to expand...
Thank you
 
I did well on the run-in. I lost a few kilos in a slow way, my glucose control was excellent (99% in range according to my libre sensor) and no noticeable side effects. There was a bit less food noise and I was still enjoying food. I'm now 30 days into the randomised trial. My sensor says I'm 84% in range, my weight is slowly creeping back up and I'm eating more. I guess I'm on the placebo. However I had a bout of pneumonia in the past few weeks (after I ended the run-in) which raised my glucose for a while, so although I'm 99.9% certain I'm on the placebo I may struggle to prove it.

My A1C was tested this week, 28 days after I ended the run-in, and showed a drop from 62 to 56 which doesn't really demonstrate how well I was able to manage my glucose when on the real meds. The pneumonia may have slightly skewed my A1C results.

I really want to get it prescribed, because it was so nice not to have to worry about every meal and it lifted the diabetes anxiety that hangs over me. Can I ask, what evidence did you show your GP to get them to agree to it? I wonder if improved mental health would influence them?
 
tioca said:
I did well on the run-in. I lost a few kilos in a slow way, my glucose control was excellent (99% in range according to my libre sensor) and no noticeable side effects. There was a bit less food noise and I was still enjoying food. I'm now 30 days into the randomised trial. My sensor says I'm 84% in range, my weight is slowly creeping back up and I'm eating more. I guess I'm on the placebo. However I had a bout of pneumonia in the past few weeks (after I ended the run-in) which raised my glucose for a while, so although I'm 99.9% certain I'm on the placebo I may struggle to prove it.

My A1C was tested this week, 28 days after I ended the run-in, and showed a drop from 62 to 56 which doesn't really demonstrate how well I was able to manage my glucose when on the real meds. The pneumonia may have slightly skewed my A1C results.

I really want to get it prescribed, because it was so nice not to have to worry about every meal and it lifted the diabetes anxiety that hangs over me. Can I ask, what evidence did you show your GP to get them to agree to it? I wonder if improved mental health would influence them?
Click to expand...
I used a CGM and printed off the reports week by week. I was, able to show how the run in period and then the placebo changed the blood glucose readings, in conjunction with lifestyle changes, and it clearly showed a difference in results which correlated with the drug. I would suggest anything you could use at all would be helpful. I also got the Hba1c results after 3 months on the prescribed Rybelsus this week and it had gone down to 40 from 81 see my signature. My clinical practitioner was so excited she phoned me up to tell me as soon as she saw the results. It has also really improved my fatty liver to normal, which was, another argument I used in the consultation to get it prescribed.
 
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