Statins and liver function

Beechnut

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Type of diabetes
Prediabetes
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OLast August at a routine GP appointment I was told that I was heading for metabolic syndrome with a high waist measurement, overweight BMI 28, high blood pressure 160/85, high cholesterol 6.5 and higher than normal blood glucose which I found out later was not in the diabetic range (39). I was advised to go on statins and blood pressure medication and lose weight by eating low fat diet which I did being somewhat alarmed by what I'd heard.

As advised I had repeat blood tests in February this year, my blood glucose was up to 42, I had not lost any weight despite going on the low fat diet as I was told to. Overall cholesterol was down to 4.3 but shockingly my liver function tests were all mega high, over three times what they should be! I must say I was stunned as they were all within the normal range in August last year.

The only thing that had changed was that I was on statins and blood pressure medication. The GP explained that statins directly affect the liver and can rarely affect liver enzymes. He had a medical student with him and he said to him " This is why it is vital to do liver function tests for people starting on statins. We would never have know that this lady had liver problems until it was too late if we hadn't done the tests". I was so stunned! He told me to stop taking the statins.

Since then having read around this forum and other things like Dr David Unwins's work I have gone against my GP's advice and started on a low carb diet and I feel great. I'm losing weight and have lost my cravings. Having been constantly hungry I'm now satisfied with my meals and can go hours without eating - totally unheard of for me. I'm hoping that my next blood tests in 3 weeks time show better liver function tests, the GP seems to think they will but this is so worrying. I wondered if anyone else had this experience with statins?
 
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lovinglife

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I had the same experience with statins, I was given Atorvastatin and my liver count went through the roof after 2 weeks, the GP himself actually called me to tell me to stop taking them immediately, he sent me for a liver scan but that was fine including no fatty liver, and my next blood test 6 weeks late my liver count was down a bit, the one after that was back to pre statin level so try not to worry, it’s now on my records as allergic to statins
 
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Deleted member 596235

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... I wondered if anyone else had this experience with statins?
I've been taking Atorvastatin 20mg as a maintenance dose
for about three years, with no negative effects on my liver
function.

 

lovinglife

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Thanks lovinglife that's very reassuring. Yes ausGeoff I believe mine is a rare reaction to statins.
Yes it’s rare to have the reaction we have to statins - save me having the “you need to be on statins” though every time I see any HCP, every cloud ;)
 

Beechnut

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Messages
21
Type of diabetes
Prediabetes
Treatment type
Diet only
Haha yes but GP is threatening other meds instead of Atorvastatin to lower my cholesterol because he says that takes priority over my liver! I'm very wary of taking anything that messes with my liver but it's hard to know which is the most important experts do not always agree on this. I'm hoping new low carb diet will help with future results but again so many say all that fat is not going to lower your cholesterol. Hey ho
 

searley

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Haha yes but GP is threatening other meds instead of Atorvastatin to lower my cholesterol because he says that takes priority over my liver! I'm very wary of taking anything that messes with my liver but it's hard to know which is the most important experts do not always agree on this. I'm hoping new low carb diet will help with future results but again so many say all that fat is not going to lower your cholesterol. Hey ho

I don’t get on with statins as the raise my BG, I have an alternative to statins that is both reducing my cholesterol and not affecting me in any other way
 

Melgar

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I'm on 10mg of Rosuvastatin I've been on them since last November. I had resisted them for several years as my Triglycerides were low at 0.53 mmol/Ls and my HDL was normal it was LDLs that were above normal (4.41) . I must say I am pleased with the results. Not a dramatic decrease in LDL's, but in the normal range. I see that my alanine aminotransferase (ALT) has risen from 13 U/L to 17 U/L. My Dr said that was nothing to worry about as it's still well within the normal range. Other than that, no other issues.
I have attached a study on Statins and Liver Injury for those interested.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3983981/
 
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lovinglife

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There are alternatives to statins I take a low dose of Ezetimibe which dropped my cholesterol quite nicely and I have no side effects

 
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Chris24Main

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Ushthetaff

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I’ve been on statins as long as I can remember I get total blood test every month due to dialysis treatment no problems recorded
 

Chris24Main

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That's interesting @Usethetaff - the clinical guidelines post 2013 actually call for not starting statins in the event of dialysis being necessary, however to continue if a patient is already taking statins. The actual phrase in use is "given the lack of clinical benefit for lipid reduction reported in large clinical trials." -

so I don't fall foul of the forum rules: