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Statins - good or bad - what does the research say?
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<blockquote data-quote="Oldvatr" data-source="post: 1021462" data-attributes="member: 196898"><p>Hi [USER=195124]@seadragon[/USER] I have not followed the Framlingham study, but I have serious doubts about the ASCOT trial which has been put forward as justification for using a statin to reduce mortality rates in the general population. I have quoted the results reported by that report for <<all- causes>> deaths in the 11 years of follow up. That showed that the benefit from the statin was considerably lower than claimed by the authors of the report in their conclusion. I found the actual benefit to be in the order of 3% not 36%. Now I look at the same results but inrespect of cardio vascular only events, then the benefit is even smaller (reducing to 0.3%) which is pitiful. This result cannot support a declaration of <<A significant reduction>> since it is down in the noise level statisticlally speaking . The Report even quotes P= 0.05 as being significant Yes it is but in the wrong direction - the result is rubbish and it shows that the standard deviation is all over the place.</p><p>I also note that the extended report also states that the results were adjusted to allow for the cross contamination effect from them running a hypertension study in parallel with the statin trial. However, it seems they allowed for a difference between the two hypertension therapies, but not for the fact that the hypertension meds were probably affecting the trial itself.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1021462, member: 196898"] Hi [USER=195124]@seadragon[/USER] I have not followed the Framlingham study, but I have serious doubts about the ASCOT trial which has been put forward as justification for using a statin to reduce mortality rates in the general population. I have quoted the results reported by that report for <<all- causes>> deaths in the 11 years of follow up. That showed that the benefit from the statin was considerably lower than claimed by the authors of the report in their conclusion. I found the actual benefit to be in the order of 3% not 36%. Now I look at the same results but inrespect of cardio vascular only events, then the benefit is even smaller (reducing to 0.3%) which is pitiful. This result cannot support a declaration of <<A significant reduction>> since it is down in the noise level statisticlally speaking . The Report even quotes P= 0.05 as being significant Yes it is but in the wrong direction - the result is rubbish and it shows that the standard deviation is all over the place. I also note that the extended report also states that the results were adjusted to allow for the cross contamination effect from them running a hypertension study in parallel with the statin trial. However, it seems they allowed for a difference between the two hypertension therapies, but not for the fact that the hypertension meds were probably affecting the trial itself. [/QUOTE]
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