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Statins - good or bad - what does the research say?
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<blockquote data-quote="Oldvatr" data-source="post: 1056185" data-attributes="member: 196898"><p>Hi [USER=113749]@LucySW[/USER] Thank you for bringing this to our attention. I am by no means fluent in statistics, but I did have a quick look at some RCT reports for this thread, and I drew much the same conclusions. i did not have to go far to find that the conclusions in these reports was not related to the data shown in the body of the reports, and i am pleased that a more thorough analysis has reached the same conclusion. </p><p></p><p>I have further researched in terms of the PETO statistical method used, and I have found that quite clearly there is inbuilt bias when deriving the risk ratio values that increases logarithmically the bigger the difference between the observed and expected results are. I provide a link to one such report, but it is heavy reading.</p><p><a href="http://www.kbs.med.kyoto-u.ac.jp/SatoBIC05.pdf" target="_blank">http://www.kbs.med.kyoto-u.ac.jp/SatoBIC05.pdf</a></p><p></p><p>I am surprised that the follow up report you provided did not pick up on this since the methodology originally used has been shown to be totally flawed. Mind you, the two reports I looked at were ignored from the analysis you linked to, so maybe they had already rejected them.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1056185, member: 196898"] Hi [USER=113749]@LucySW[/USER] Thank you for bringing this to our attention. I am by no means fluent in statistics, but I did have a quick look at some RCT reports for this thread, and I drew much the same conclusions. i did not have to go far to find that the conclusions in these reports was not related to the data shown in the body of the reports, and i am pleased that a more thorough analysis has reached the same conclusion. I have further researched in terms of the PETO statistical method used, and I have found that quite clearly there is inbuilt bias when deriving the risk ratio values that increases logarithmically the bigger the difference between the observed and expected results are. I provide a link to one such report, but it is heavy reading. [URL]http://www.kbs.med.kyoto-u.ac.jp/SatoBIC05.pdf[/URL] I am surprised that the follow up report you provided did not pick up on this since the methodology originally used has been shown to be totally flawed. Mind you, the two reports I looked at were ignored from the analysis you linked to, so maybe they had already rejected them. [/QUOTE]
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