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Still drinking Cola drinks? Not such a good idea...
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<blockquote data-quote="Indy51" data-source="post: 1929650" data-attributes="member: 48386"><p>[USER=85197]@zand[/USER] - this pretty much confirms your experience if Colas were your soft drink of choice.</p><p></p><p>Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis</p><p></p><p><a href="https://www.nature.com/articles/s41598-018-35071-6.epdf?" target="_blank">https://www.nature.com/articles/s41598-018-35071-6.epdf?</a></p><p></p><p>Mouse study - but mechanism seems translatable to humans.</p><p></p><p><em>Caramel colours are the preferential food colouring agent globally, reaches wide age groups through </em></p><p><em>eatables. Colas, a sweetened carbonated drink are most common caramel coloured beverage and its </em></p><p><em>consumption is linked with diabetes, obesity, pancreatic cancer and other endocrine disorders. A major </em></p><p><em>by-product produced during caramelization is 4-methylimidazole (4-MEI) that is detected in noteworthy </em></p><p><em>concentrations in colas and other beverages. Previous studies revealed the neurotoxic and carcinogenic </em></p><p><em>potential of 4-MEI in animals at higher doses but the effect of 4-MEI at theoretical maximum daily intake </em></p><p><em>dose on glucose homeostasis is unexplored. Here, mice treated with 4-MEI (32μg/kg bodyweight/day) </em></p><p><em>for seven weeks exhibited severe hypoglycaemia and hyperinsulinemia mediated by hyperplasia of </em></p><p><em>pancreatic beta cells and induces metabolic alterations. On combinatorial treatment, 4-MEI suppressed </em></p><p><em>the glucogenic potential of non-artificial sweeteners and promotes lipogenesis. Furthermore, increased </em></p><p><em>levels of C-peptide, LDL-cholesterol and triglycerides were observed in the humans with regular intake </em></p><p><em>of 4-MEI containing beverages. In summary, 4-MEI induced pancreatic beta cell hyperplasia and leads </em></p><p><em>to disruption of glucose and lipid homeostasis. This study suggests the need for further assessment and </em></p><p><em>reconsideration of the wide usage of 4-MEI containing caramels as food additives.</em></p></blockquote><p></p>
[QUOTE="Indy51, post: 1929650, member: 48386"] [USER=85197]@zand[/USER] - this pretty much confirms your experience if Colas were your soft drink of choice. Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis [URL]https://www.nature.com/articles/s41598-018-35071-6.epdf?[/URL] Mouse study - but mechanism seems translatable to humans. [I]Caramel colours are the preferential food colouring agent globally, reaches wide age groups through eatables. Colas, a sweetened carbonated drink are most common caramel coloured beverage and its consumption is linked with diabetes, obesity, pancreatic cancer and other endocrine disorders. A major by-product produced during caramelization is 4-methylimidazole (4-MEI) that is detected in noteworthy concentrations in colas and other beverages. Previous studies revealed the neurotoxic and carcinogenic potential of 4-MEI in animals at higher doses but the effect of 4-MEI at theoretical maximum daily intake dose on glucose homeostasis is unexplored. Here, mice treated with 4-MEI (32μg/kg bodyweight/day) for seven weeks exhibited severe hypoglycaemia and hyperinsulinemia mediated by hyperplasia of pancreatic beta cells and induces metabolic alterations. On combinatorial treatment, 4-MEI suppressed the glucogenic potential of non-artificial sweeteners and promotes lipogenesis. Furthermore, increased levels of C-peptide, LDL-cholesterol and triglycerides were observed in the humans with regular intake of 4-MEI containing beverages. In summary, 4-MEI induced pancreatic beta cell hyperplasia and leads to disruption of glucose and lipid homeostasis. This study suggests the need for further assessment and reconsideration of the wide usage of 4-MEI containing caramels as food additives.[/I] [/QUOTE]
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