Stop Glicazide to lose weight?

Metformin is infamous for its effect on the gut - when I tried it I was unable to leave the house some days, but other people find it does become better with time, I found it got worse, and I got pain, itching all over, muscle twitching and just had to give it up. I tried all ways to take it, before eating, during, after with a large glass of water, and there were sometimes intervals of half a day when it seemed better, but the next tablet brought it all full on again. I think it really is just a matter of luck if you can take it or not, so the only way would be to try it, but not when you have appointments to keep.

Hello @Nikkim58 and Welcome to the Forum . Some people cannot take the Standard Metformin as it can cause stomach problems and also give you diarrhoea. Whereas the Slow Release Metformin is much better tolerated by people.
We are not allowed to tell you what to do as regards medications - You need to discuss with your GP any concerns about stopping and/or changing medications.

I've been slowly losing weight while on Gliclazide, but had to lower my daily calories a bit below what is recommended for sedentary people. I also can't exercise, and am mostly stuck on the couch, but can walk short distances around the house. Admittedly, Gliclazide doesn't seem to have any impact on my blood sugars.

Have you been counting carbs and calories? That's how I was able to determine that 1800-2000 is too much for me, and I need 1600-1800 to lose weight, which I can usually do without feeling hungry.

Hi @Nikkim58 - A lot of Forum Members follow the LCHF Diet (Low Carb High Fat) - it helps to lower the Blood Sugars, HBA1C and with weight loss also.
Take a look at the following 2 sites:

http://www.dietdoctor.com/low-carb/60-seconds
http://www.dietdoctor.com/lchf

Talk to your GP, or preferably a specialist in diabetes, about this. There are things you can take other than Gliclazide. It might be something more expensive though, which is why it'll never be offered as a first choice, but if you don't highlight your difficulties to the professionals they can't offer alternatives.

Hi. I would certainly stay with the Metformin SR as it doesn't affect weight and helps BS a bit. You might want to discuss the Gliclazide with the GP? It works by stimulating the pancreas to produce more insulin and many T2s will already have enough or too much from insulin resistance. It can cause weight gain if any extra insulin production is matched by eating too many carbs. GPs often seem to throw-in Gliclazide with Metformin 'just in case it helps' without doing a c-peptide test. With an insulin resistant T2 it won't do any harm or much good either. It may help long-term T2s where the pancreas has been damaged thru continued high BS.