There are separate antibodies for the insulin molecule, beta cells, and other cells.
So one could theoretically produce enough insulin just fine with healthy beta cells, but as soon as they are released, WHAM, gone.
I've asked that exact question on my blog, several times, and despite scouring sci hub have found no answers, so please, if you know the answer, or know someone who does, then please, enlighten me. I'm serious, I'm here to learn, and have no pretense of anything but ignorance about how insulin specific antibodies exist but only attack endogenous insulin molecules rather than synthetic, exogenous insulin. Does humalog evade IA2 antibodies? If so, how? If the researchers think that pre-training babies to tolerate the insulin molecule can help avoid type 1 diabetes, then they must have the answers to this riddle. It is indeed a riddle that I've heard basically zero about. I believe I even asked the researchers involved in powdered insulin and they don't know.
However, I'm fairly certain that I know about this topic than the vast majority of diabetics on this website, despite my inability to answer this question. The very existence of insulin-specific antibodies must mean the auto-immunity is reacting to a molecule shape it considers foreign. Therein lies the answer, I believe. Junk / damaged insulin is being produced by damaged beta cells that are infected by enteroviruses which are present in perhaps 99% of the human population.
The BCG trial was discussed on this forum. As was pointed out in the discussions at the time, the BCG sample size was very small: https://blogs.diabetes.org.uk/?p=10671For instance, recent study results prove that both BCG and verapamil have measurable improvements for type 1 diabetics. And nobody's really talking about it here. I wonder why that is.
There are separate antibodies for the insulin molecule, beta cells, and other cells.
So one could theoretically produce enough insulin just fine with healthy beta cells, but as soon as they are released, WHAM, gone.
Recent news reports, shared right here on DCOUK, suggest it's damaged or "junk" insulin molecules and beta cells that are attacked by the immune system, so the disease itself isn't an auto-immune malfunction per se, but a perfectly valid immune response to damaged cells which it considers foreign, perhaps creating damaged insulin from an enterovirus (CVB-1). This is confirmed by the fact that all type 1s have some endogenous insulin production and thus functional, mature beta cells, throughout their lives (via both cp tests and autopsies proving it).
I sometimes wonder if any large percentage of those who post in this forum read the news section here, no offense. This data is well-known, and has been for years. Auto-Insulin-antibodies are not news, they've been known for decades now.
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