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Study: Very Low Calorie Diet Reverses Hyperglycemia

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Biggles2

Well-Known Member
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This is an interesting study published in the last few days:

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30616-2

This accessible article from Yale News sums it up nicely:

Study reveals how a very low calorie diet can reverse type 2 diabetes

https://news.yale.edu/2017/11/09/study-reveals-how-very-low-calorie-diet-can-reverse-type-2-diabetes

Here is an interesting snippet from the Yale News article:

'“These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with type 2 diabetes,” Shulman said.'​

That statement does beg the following questions: If VLCD reverses hyperglycemia, then why on earth would they need to develop novel drug targets to more effectively treat patients with T2DM? Wouldn't a VLCD do the trick, or variations thereof - such as intermittent fasting?
 
Biggles2 said:
That statement does beg the following questions: If VLCD reverses hyperglycemia, then why on earth would they need to develop novel drug targets to more effectively treat patients with T2DM? Wouldn't a VLCD do the trick, or variations thereof - such as intermittent fasting?
Click to expand...

Not quite sure why they took the ND and did it on mice when it has already been trialled on people..? ok not that many so far but still real people
As for your last point.. where's the money to be made out of changing our way of eating..?
 
Biggles2 said:
This is an interesting study published in the last few days:

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30616-2

This accessible article from Yale News sums it up nicely:

Study reveals how a very low calorie diet can reverse type 2 diabetes

https://news.yale.edu/2017/11/09/study-reveals-how-very-low-calorie-diet-can-reverse-type-2-diabetes

Here is an interesting snippet from the Yale News article:

'“These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with type 2 diabetes,” Shulman said.'​

That statement does beg the following questions: If VLCD reverses hyperglycemia, then why on earth would they need to develop novel drug targets to more effectively treat patients with T2DM? Wouldn't a VLCD do the trick, or variations thereof - such as intermittent fasting?
Click to expand...

No money in promoting better diet. The big bucks are in the pills. If a drug is developed then attitudes will never change and nothing upsets the status quo re Big Pharma and Big Food.
 
Didn't Dr Roy Taylor's team already showed this on human study in 2011?
http://www.diabetes.co.uk/forum/blo...e-2-diabetes-etiology-and-reversibility.1828/
Within 7 days of instituting a substantial negative calorie balance by either dietary intervention or bariatric surgery, fasting plasma glucose levels can normalize. This rapid change relates to a substantial fall in liver fat content and return of normal hepatic insulin sensitivity. Over 8 weeks, first phase and maximal rates of insulin secretion steadily return to normal, and this change is in step with steadily decreasing pancreatic fat content.
Click to expand...
 
Biggles2 said:
'“These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with type 2 diabetes,” Shulman said.'
Click to expand...

It simply goes to show that if we get results like this with a pill...it would have been hailed as revolutionary, ground-breaking, game changer and goes on to be a billion dollar blockbuster...oops it is a dangerous and unsustainable lifestyle change.
12232713_10153806535704445_7312677211844994735_o.jpg
 
bulkbiker said:
Not quite sure why they took the ND and did it on mice when it has already been trialled on people..? ok not that many so far but still real people
As for your last point.. where's the money to be made out of changing our way of eating..?
Click to expand...

Both of my questions were tongue in cheek! I was going to use "Who knew?" as the title of the thread, LOL!

I thought of you @bulkbiker when I initially read this article! It occurred to me that they would have learnt more just by reading a few of your posts - and saved themselves a bucketful of money at the same time! Too bad they do not drop by this website now and again to read of real people's success. But we're not scientists, so apparently our success doesn't count, not to mention that there is no money to be made if people have success with 'lifestyle' measures.

But seriously, when you think of all the grant money that goes to fund this type of research - it would be better spent on providing us with the tools we need to monitor our blood glucose so that we can effectively manage our conditions.

As to developing novel drugs to mimic the effects of a VLCD - well, I think that just confirms their mindset: the belief that we are to blame for our condition because we do not have the willpower to follow their standard issue dietary advice - which, of course, is the root cause of many of our metabolic problems in the first place. They do not believe that people have the capacity to make the dietary changes they need to make to optimize their health. Of course we do, and this forum provides more and more proof every day.
 
Guzzler said:
No money in promoting better diet. The big bucks are in the pills. If a drug is developed then attitudes will never change and nothing upsets the status quo re Big Pharma and Big Food.
Click to expand...
I totally agree @Guzzler! And of course, they provide funding for the advocacy organizations that produce the guidelines. Mmm....
 
Biggles2 said:
'“These results, if confirmed in humans, will provide us with novel drug targets to more effectively treat patients with type 2 diabetes,” Shulman said.'
Click to expand...

I wonder what drugs they're thinking of? Something to stop you feeling hungry, although when I tried the VLCal approach I didn't really feel that hungry.

I felt a bit incensed, it's as if there has been no research in this area and that the study authors have come up with a new idea. If it's just academic research then it's not even novel ( Interestingly new or unusual). I think if it is academic research then Professor Taylor of Newcastle University deserves a mention or acknowledgement.

I've eMail'd the media contact ([email protected]), just to make him aware that things do happen outside the U.S.
 
Biggles2 said:
Both of my questions were tongue in cheek! I was going to use "Who knew?" as the title of the thread, LOL!

I thought of you @bulkbiker when I initially read this article! It occurred to me that they would have learnt more just by reading a few of your posts - and saved themselves a bucketful of money at the same time! Too bad they do not drop by this website now and again to read of real people's success. But we're not scientists, so apparently our success doesn't count, not to mention that there is no money to be made if people have success with 'lifestyle' measures.

But seriously, when you think of all the grant money that goes to fund this type of research - it would be better spent on providing us with the tools we need to monitor our blood glucose so that we can effectively manage our conditions.

As to developing novel drugs to mimic the effects of a VLCD - well, I think that just confirms their mindset: the belief that we are to blame for our condition because we do not have the willpower to follow their standard issue dietary advice - which, of course, is the root cause of many of our metabolic problems in the first place. They do not believe that people have the capacity to make the dietary changes they need to make to optimize their health. Of course we do, and this forum provides more and more proof every day.
Click to expand...

Oops sorry I think we could do with an irony emoji!
 
DavidGrahamJones said:
I felt a bit incensed, it's as if there has been no research in this area and that the study authors have come up with a new idea. If it's just academic research then it's not even novel ( Interestingly new or unusual). I think if it is academic research then Professor Taylor of Newcastle University deserves a mention or acknowledgement.
Click to expand...

Don't feel incensed @DavidGrahamJones this is business as usual in Academia! In those rarefied circles, the whole point of doing research and getting published is to bring recognition,funding and prestige to your own university and team. It is a very, very competitive environment. There is robust competition in terms of getting published first (remember the intense competition between AIDS researchers in France and the US in the 1980's?).

Dr. Taylor's work (and his latest work is under embargo until the Diabetes conference in early December) would have surfaced as part of a literature review. Not to mention the body of work on the effects of rapid weight loss after bariatric surgery. Dr. Taylor's work focuses on short-term VLCD in humans as opposed to rodents, so it is much higher up on the research "food chain" than studies using the rodent model. When his work is released, it will bring prestige and funding to Newcastle University as well as personal fulfillment to Dr. Taylor and his team of researchers. Watch for the press releases from Newcastle University after the release of Dr. Taylor's research!

But what about the “Wisdom of Crowds” abundantly evident every day on this forum? What about the wisdom generated and shared by us mere mortals? Individuals who are transforming our lives as a result of our new knowledge? And freely sharing it (along with our improved markers) with others seeking to improve their lives too? Sometimes the academics get tied up in the minutiae. Real people have lives to live, and health to maintain. Our time is limited, so we don’t have time to wait for Academia to catch up!

If you have not yet had a chance, check out the video clip shared by @Indy51 earlier in the week: Diet, Health and the Wisdom of Crowds”, post # 56 on the following link:

http://www.diabetes.co.uk/forum/threads/goodbye.129113/page-3#post-1617218

I found it riveting. I especially loved the following quote from the physicist Max Planck: “Science advances one funeral at a time”. For more about this concept, take a look at the following article:

http://www.nber.org/digest/mar16/w21788.html
 
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