Tacrolimos

[Maddiemo1]

Hi. Is there anyone here on tacrolimos after having a transplant? I have been reading that they course diabetes. I'm on them and I'm sure that is why I'm pre diabetic now. Just wondering if anyone else is in the same situation.

 

[juliencrew]

hello there I had a pancreas transplant 5 years ago they put me on tacrolimas and i aske the consultant to change them because i am a diabet and have been for 38 years i did belive my high sugars then was down to that tablet they changed the tablet and my levels went down so for me it gave me higher glucose levels i would ask to see them for advice. ggod luck.
just adding the doner panceas had to be removed after 6months my body rejected it. they have more success with kidney transplants

 

[Sid Bonkers]

Hi Maddiemo1, there is apparently a known link between high blood sugars and tacrolimas, I found this on the net that you may find useful.

* Patients who use tacrolimus after an organ transplant may have an increased risk of developing high blood sugar or diabetes. The risk is higher among black and Hispanic patients after a kidney transplant. High blood sugar may make you feel confused, drowsy, hungry, or thirsty. It can also make you flush, breathe faster, urinate more often, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

* Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Read more at http://www.drugs.com/cdi/tacrolimus.htm ... JCA3bJW.99

There are several other drugs known to cause high blood sugars and diabetes including Prednisolone which was the cause of my own diabetes after a long term maintenance dose, although I may well have died without it so I have to accept my diabetes and be thankful that I am still here

 

[Superchip]

Well I had a heart transplant 18 years ago and started off on neoral cyclosporin for about 5 years then put on to tacrolimus for the next 10 years, about the same time I started with diabetes, since then I've been on a rather expensive drug called cellcept ( £83 a box of 50 ) !

I wish that I had been aware of a link to diabetes !

Superchip

 

[SAH154]

Tacrolimus in doses too high can give someone a form of type 2 diabetes, but it is reversible. It was explained to me that it can bond with insulin and seriously weaken it's strength. If you suffer rejection they may up the levels of Tacrolimus and the guidelines for blood levels of the drug are dictated by the type of organ transplanted as the pancreas TX needs higher levels of it that a kidney only if that makes sense?