OGTT: @ 2 hours after glucose I was 7.4 mmol
How are these for OGTT please?
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That's a resounding pass!
It's a none diabetic number, congratulations.
It's in the normal range that none diabetics will return to after that time.
Have a read of the link here
http://www.diabetes.co.uk/oral-glucose-tolerance-test.html
Oh wow...that's great. I guess my fasting may have skewed it? Although my A1C should give me a broader view over the last 3 months. Thanks
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It all depends on carbs, I would peak at c.60mins after carbs and I could be on my way to an hypo at +120mins if I walked about. Then again I do have R.H.
But we all have varied responses to carbs and yours was good at +2hours. Perhaps your well on your way to a cure, Kevin?
regards
D.
Your HbA1c may be skewed because of your fasting. Don't forget your recently created haemoglobin won't have glycated and the test isn't a true average over up to 3 month's as it is weighted towards the most recent week or two.
How are your results @KevinPotts - I've been trying to follow the thread but failed miserably ... talk of stuff I don't know about - have you got your HbA1c or do you need to wait?
Sorry for being a dunce
The most recent four weeks.Your HbA1c
the test isn't a true average over up to 3 month's as it is weighted towards the most recent week or two.
My reactions so far; others might come to mind. The numbers in your signature represent amazing, amazing reversal in 3 months prior to today's test.
Today's OGTT yielded: time 0 hour - 1 h - 2h; FPG 5.1 - 9.7 - 7.4.
1. Officially normoglycaemic, but the levels are still too high. The criterion for positivity for this test is 7.8 or higher at 2.0 h. (This makes 7.4 a near thing.) However, the only parameter taken into consideration is the 2 hour value. The test result could be negative even with a 1 h value of 14.0.
2. There was a study of OGTT results in normoglycaemic subjects. There was a wide variety of glucose disposal agility among them. But for peak postprandial value (peak, not 2 h), no subgroup had an average greater than 7.8. This tells me that >7.8 is pathological. 9.7 is absolutely pathological, because it's very close to the renal threshold (the could be slight individual variation in the renal threshold, too). My peak used to be >10.0 and probably still is.
3. Another study using the OGTT concluded that the criterion of 8.6 at 1.0 h was statistically a better predictor of progression to diabetes than 7.8 at 2.0 h. This is just one study. The rest of the diabetes world did not pursue this finding.
4. When somebody used the phrase, "better predictor", I assume they were referring to predictor of progression to diabetes (within 5 to 10 years). We might put 'progression diabetes prediction' into the search engine, to compare the three diagnostic tests.
5. When taking the OGTT, it's not desirable to be anywhere near 7.8 at 2 h still. If it is taking 3 or 4 hours to regain fasting level after eating only sugar, then you need the saving grace of lower peak levels, perhaps 7.0. Granted, hyperglycaemia consists in the postprandial response being too high and/or too wide (time dimension). Nevertheless, if you are thinking big, i.e. aiming to fully reverse hyperglycaemic test results, that entails aiming to shrink below 7.0 mmol/l and below 2.0 h. The A1c is the average of 12 weeks worth of fasting BG's and postprandial glucose response curves. Each area under a postprandial hump (response curve) -- i.e., every meal -- will increment the A1c. Lowering the A1c entails some combination of lowering the baseline and shrinking the humps.
6. The biggest clinical shortcoming of the OGTT is that it's very inconsistent. Repetitions are fairly likely to be some positive, some negative. This is discussed in two articles, pro and con, from October 2002. (Diabetes Care magazine, 25(10), care.diabetesjournals.org > issue archive.) Point: a glucose tolerance test is important for clinical practice. DOI: 10.2337. Counterpoint: the oral glucose tolerance test is superfluous. DOI: 10.2337.
7. It's nice that both insulin and glucose were measured every half hour. With this data, you could try to do some arithmetic and compare the result to Figure 3 in this article (DeFronzo 2009 April, http://diabetes.diabetesjournals.org/content/58/4/773). I suppose for the IR, he used HOMA-IR (it'll be disclosed in the article). The measurements at 0 hours will yield this value, then you can plot it on the HOMA-IR graph (online).
8. It's a pity that they still use these backward tests, the fasting and the OGTT. They should already be taping a continuous meter to one's belly for 3 days, or a week.
My reactions so far; others might come to mind. The numbers in your signature represent amazing, amazing reversal in 3 months prior to today's test.
Today's OGTT yielded: time 0 hour - 1 h - 2h; FPG 5.1 - 9.7 - 7.4.
1. Officially normoglycaemic, but the levels are still too high. The criterion for positivity for this test is 7.8 or higher at 2.0 h. (This makes 7.4 a near thing.) However, the only parameter taken into consideration is the 2 hour value. The test result could be negative even with a 1 h value of 14.0.
2. There was a study of OGTT results in normoglycaemic subjects. There was a wide variety of glucose disposal agility among them. But for peak postprandial value (peak, not 2 h), no subgroup had an average greater than 7.8. This tells me that >7.8 is pathological. 9.7 is absolutely pathological, because it's very close to the renal threshold (the could be slight individual variation in the renal threshold, too). My peak used to be >10.0 and probably still is.
3. Another study using the OGTT concluded that the criterion of 8.6 at 1.0 h was statistically a better predictor of progression to diabetes than 7.8 at 2.0 h. This is just one study. The rest of the diabetes world did not pursue this finding.
4. When somebody used the phrase, "better predictor", I assume they were referring to predictor of progression to diabetes (within 5 to 10 years). We might put 'progression diabetes prediction' into the search engine, to compare the three diagnostic tests.
5. When taking the OGTT, it's not desirable to be anywhere near 7.8 at 2 h still. If it is taking 3 or 4 hours to regain fasting level after eating only sugar, then you need the saving grace of lower peak levels, perhaps 7.0. Granted, hyperglycaemia consists in the postprandial response being too high and/or too wide (time dimension). Nevertheless, if you are thinking big, i.e. aiming to fully reverse hyperglycaemic test results, that entails aiming to shrink below 7.0 mmol/l and below 2.0 h. The A1c is the average of 12 weeks worth of fasting BG's and postprandial glucose response curves. Each area under a postprandial hump (response curve) -- i.e., every meal -- will increment the A1c. Lowering the A1c entails some combination of lowering the baseline and shrinking the humps.
6. The biggest clinical shortcoming of the OGTT is that it's very inconsistent. Repetitions are fairly likely to be some positive, some negative. This is discussed in two articles, pro and con, from October 2002. (Diabetes Care magazine, 25(10), care.diabetesjournals.org > issue archive.) Point: a glucose tolerance test is important for clinical practice. DOI: 10.2337. Counterpoint: the oral glucose tolerance test is superfluous. DOI: 10.2337.
7. It's nice that both insulin and glucose were measured every half hour. With this data, you could try to do some arithmetic and compare the result to Figure 3 in this article (DeFronzo 2009 April, http://diabetes.diabetesjournals.org/content/58/4/773). I suppose for the IR, he used HOMA-IR (it'll be disclosed in the article). The measurements at 0 hours will yield this value, then you can plot it on the HOMA-IR graph (online).
8. It's a pity that they still use these backward tests, the fasting and the OGTT. They should already be taping a continuous meter to one's belly for 3 days, or a week.
The most recent four weeks.
Are you a medic?
It bring up something I have seen in myself, that I am better off with a 45 minute and then an hour and a half test for spikes.
One doc told me that the GTT with additional testing hourly for a while cn show your bounce backability in the same wasy as taking blood pressures pulse rates and oxygen levels ever minute for ten minutes after intense 5 minute exercise can show how quick you get your pulse rate up and how quick you are to recover.
Sometimes I fool around with various breathing techniques to see what changes
Your HbA1c may be skewed because of your fasting. Don't forget your recently created haemoglobin won't have glycated and the test isn't a true average over up to 3 month's as it is weighted towards the most recent week or two.
No, but I do have a bachelor's in the science/engineering area. As with some others on this forum, I once received notice of a high A1c test, accompanied by some ill informed advice and stern reactions from HCP's. This spurred me to surf the Web. Acquired a new hobby.
There's a lot more for me to google on. I have a couple of other things that were diagnosed as the embryonic stages of aging related illnesses. I have three conditions that may stall at the harmless stage, or may progress to malignant in 10 years. If I were confident that my A1c will never cross into 48+ and stay there, I might be less eager about this topic. These postmeal rises of 5.5 mmol/L would still be disturbing.
Imagine somebody usually having a steady fasting level of 5.4. Imagine that they eat in such a way that for 24 hours straight, the BG is 7.0 (many people would consider a postmeal of 7.0 not bad). This would represent a rise in A1c of 11 IFCC units, from 31 to 42 (= 1.0% glycation). One meal where this glucose response was 7.0 for exactly 2 hours would contribute about 1 IFCC unit. (In fact, the BG ramps up and ramps down). If the rise lasts for 3 hours instead, the increase in the day's A1c would be half again as much.
Your reversal since April is fantastic. The trend is excellent. By not drinking four cans of fizzy drink at all once, maybe those rises of 4.5, 5.0 mmol/L can be avoided.
It depends a lot on the replacement period of individuals hemoglobin, and this can vary from person to person.
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