Type 1s - why it might be hard to keep blood sugars normal

[NicoleC1971]

https://www.jci.org/articles/view/60016/figure/5

Interesting twitter thread led me here (via Gabor Endosi who's worth a follow on matters metabolic) re the differences between insulin you inject versus insulin you make yourself.
Warning it involves mice but the interesting bit is the concept that exogenous insulin doesn't inhibit insulin's antagonist hormone - glucagon due to the way it hits the liver. So you get plenty to push energy into the cells but it s less effective at the muscular and liver level.

 

[Robert Henderson]

Keeping blood sugar levels close to normal will be challenging for T1 because some causes are things that you cannot control (hot and humid weather, interruptions in usual schedules due to travel, spending time at high altitude, going through puberty, or stress). Not taking enough insulin can lead to hyperglycemia (like missing a dose or not taking enough insulin for the carbs you ate). People with T1D can have episodes of hyperglycemia every day. Although this can be frustrating, it rarely creates a medical emergency. All these things make it difficult to control.