Unexplained highs in the late evening

[michael_n]

Ok, back to this thread. I've been injecting Lantus since starting this thread and after three or four bad days, it seemed to get better. BG would still rise in the evening, but it took about 3u of NovoRapid to get it to normal levels. During the day, everything was perfect. Last night, disaster struck - it was 200 mg/dl at 12 am and I injected 2u of NR which I though would at least bring it under 150. But I woke up with 300 mg/dl and struggled all morning to get it to a decent level. I injected another 8u (2 by 2), not counting the 10u I did in the morning. It was decent enough after lunch and in the early evening. Now it is 290 mg/dl. It was 260 mg/dl 40 minutes ago and I injected only 2u NR to see how it would react. I just don't know what to do anymore.

Can't understand these 180 degree turns from one day to another and why on Earth insulin doesn't lower my BH....

 

[Leeannea]

Hi. I was also experiencing highs after midnight. I don’t know if it was a coincidence but I started eating less than 15 grams of protein and no saturated fats for dinner, which then consisted of lots of low carb vegetables eg curries and the highs stopped. This worked for me. It might be worth a try. Good luck

 

[rmz80]

May be worth reading up on a drugs “half life”. This the time before the body has used half a drug. Below is an extract from a Google search.

When Lantus was first launched, it was marketed as a "24-hour-insulin," but, with a half-life of 12 hours, insulin glargine always struggled to live up to that promise and has found itself eclipsed by the long-acting insulin degludec (Tresiba, Novo Nordisk)


Your Levemir is only listed as 5 to 7 hours half life

 

[michael_n]

Here I am once again dealing with the same problems. I'm still on Lantus and get highs and insulin resistance starting from 5 pm, regardless of what and when I eat. I've tried splitting the Lantus dose and I got the same results. There are days when this doesn't happen and everything works as it should, but those are pretty rare.

I've also been diagnosed with chronic sinusitis and am seeing an ENT specialist next week, but I don't think this condition could explain the glucose levels rising like clockwork in the late afternoon. I will see my doctor at the end of the month and discuss this issue again, as well as switching to Tresiba if possible. In the meantime, I am open to any ideas that could provide a solution. Thanks!

 

[Shannon27]

Here I am once again dealing with the same problems. I'm still on Lantus and get highs and insulin resistance starting from 5 pm, regardless of what and when I eat. I've tried splitting the Lantus dose and I got the same results. There are days when this doesn't happen and everything works as it should, but those are pretty rare.

I've also been diagnosed with chronic sinusitis and am seeing an ENT specialist next week, but I don't think this condition could explain the glucose levels rising like clockwork in the late afternoon. I will see my doctor at the end of the month and discuss this issue again, as well as switching to Tresiba if possible. In the meantime, I am open to any ideas that could provide a solution. Thanks!

Lantus doesn't actually last a full day in your body - it's supposed to last UP TO 24hrs but i found it started running out after about 22hrs, as i was regularly going high in the evenings. So a daily injection at the same time each day means you're not fully covered. I went from Lantus to Tresiba for this reason - i was struggling to manage the highs, and its loads better Tresiba lasts 42hours give or take, so you're always covered since you've tried dose splitting, have you tried doing your injections at different times, as the BG spike could be your first dose running out?