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Message: <blockquote data-quote="Sid Bonkers" data-source="post: 1268353" data-attributes="member: 19121">Cheers [USER=11441]@catherinecherub[/USER] and thanks for the link, i did know about the metformin risk but hadnt realised that proton pump inhibitors (PPI's = Omeprazole etc) were implicated, or maybe I had just forgotten or not connected the information, its amazing how something focuses the mind when it becomes personal <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite2" alt=";)" title="Wink    ;)" loading="lazy" data-shortname=";)" />It seems that I am now between a rock and a hard place as I dont like taking too many paracetamol as they can adversely affect the liver and now I am not keen on taking the omeprazole which was helping to protect my stomach against the ibuprofen!!Still, I guess there are much worse problems I could have and the slow release Transtek patches have been a real game changer for me so I guess ill just have to accept some breakthrough pain.</blockquote>

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