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Type 2 Diabetes
Wake up my lazy 'B Cells'
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<blockquote data-quote="LittleGreyCat" data-source="post: 2409512" data-attributes="member: 6467"><p>I don't think that this is correct.</p><p>As far as I know the majority of T2s, at least in the early stages, are in a cycle of over producing insulin to counter ever increasing insulin resistance.</p><p>Removing fat from tissues, especially internal organs, can reduce insulin resistance and reduce the demands for insulin.</p><p>This is usually, but not always, associated with being overweight.</p><p></p><p>There are a subset of T2s who have a pancreas which is under producing insulin and often this gets worse over time.</p><p>These are often slim T2s.</p><p>If the pancreas gives up producing insulin the person falls into the confusing category of starting out as T2 but then becoming effectively T1.</p><p>There have been many discussions on this.</p><p></p><p>There was talk a couple of years back of Beta cells in T1s changing so the immune system didn't attack them.</p><p>This is an intriguing proposition because it suggests the potential to reduce or cure T1 if the cells can be both revived and protected.</p><p></p><p>Coming back to the Beta cells going dormant to cause insulin resistance; I can't see the logic behind this as T1s have dormant (or no) Beta cells and they aren't uniformly insulin resistant.</p></blockquote><p></p>
[QUOTE="LittleGreyCat, post: 2409512, member: 6467"] I don't think that this is correct. As far as I know the majority of T2s, at least in the early stages, are in a cycle of over producing insulin to counter ever increasing insulin resistance. Removing fat from tissues, especially internal organs, can reduce insulin resistance and reduce the demands for insulin. This is usually, but not always, associated with being overweight. There are a subset of T2s who have a pancreas which is under producing insulin and often this gets worse over time. These are often slim T2s. If the pancreas gives up producing insulin the person falls into the confusing category of starting out as T2 but then becoming effectively T1. There have been many discussions on this. There was talk a couple of years back of Beta cells in T1s changing so the immune system didn't attack them. This is an intriguing proposition because it suggests the potential to reduce or cure T1 if the cells can be both revived and protected. Coming back to the Beta cells going dormant to cause insulin resistance; I can't see the logic behind this as T1s have dormant (or no) Beta cells and they aren't uniformly insulin resistant. [/QUOTE]
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Wake up my lazy 'B Cells'
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