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Warwick Uni: Diabetics urged to steer clear of high fat diet

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alaska

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What do we make of this one?

The current thinking around following a high fat, low carb diet to encourage weight loss in diabetics with Type 2 Diabetes, may be misguided say researchers from Warwick Medical School.

For some time, it has been suggested that this diet aids weight loss and controls blood sugar levels, however, the Warwick research has uncovered that high fat intake encourages a rise in the amount of blood endotoxins which are bacterial fragments that provoke inflammation, with diabetic patients showing a particularly enhanced reaction.
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http://www2.warwick.ac.uk/newsandevents/pressreleases/diabetics_urged_to/

Note that the study outcomes were based upon a single meal which consisted of 75g fat, 5g carbs and 6g protein.
http://www2.warwick.ac.uk/newsandev...paper_diabetes_care_alison_harte_mar_2012.pdf

I would be interested to see further research to see how an equal calorie count of carbs -say 150g of carbs- would affect endotoxin levels in comparison with the very high fat meal in Warwick's study.

What doesn't sit quite so well with me is how definitive the interpretation of their research is: 'Diabetics urged to steer clear of high fat diet'

How many of us here eat meals consisting of 75g of fat :?: :crazy:
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

Typical poor research I'd say. Your point is right - those ratios represent about 90% fat! Who recommends that? No-one here that i know of. Perhaps they don't know that by reducing carbs you don't have to eat a kilo of lard a day. And 5 grams of carbs in 80 odd grams total? And one meal? I've not read the article but I take your word on the conclusions being based on the above, which sounds crazy to me.
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

I'm not sure how a single high fat meal constitues a "high fat" diet.

Volek and Phinney have demonstrated (and I think that it's widely accepted) that you need at least 2-3 weeks to adapt to low-carbohydrate (high-fat) diet. The subjects had with IGT and T2 diabetes had relatively high HbA1cs (5.9% and 7.5%), which suggest that few, if any of them, were adapted to low-carb diet.

If the study were conducted over a longer period, to take into account the keto-adaption phase, then the results might be relevant. All the that they are showing at the moment is that the rapid transition between a regular high-carb diet and an (almost zero) low-carb diet puts your body under stress. Anyone who has ever tried it, knows that this is true anyway.
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

This story was featured in Nursing Times.

I doubt that a high percentage of the doctors/nurses reading the article will have followed up the article by reading through the study.
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

I'd be interested in hearing Phoenix's take on it (as ever), but as far as I know, the problem with endotoxins is that they activate inflammation (a potential underlying cause of insulin insensitivity and a host of other nasty things).

That would seem to contradict what has been observed in longer studies of carbohydrate restriction (a 12 week study again from Volek's lab, but no-one else seems to be that interested in doing the work):
http://www.ncbi.nlm.nih.gov/pubmed/1804 ... d/18046594

Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation said:
In summary, a very low carbohydrate diet resulted in profound alterations in fatty acid composition and reduced inflammation compared to a low fat diet.
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As you say alaska, the problem isn't with the sience but with the sensationalist headlines.
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

phoenix said:
This puts the study into the context of other studies.
(leave you to make deductions)
http://diabetescenter.blogspot.fr/2012/ ... teria.html
I know of one T2 who regularly eats a 75% fat 20% protein diet but I wouldn't think even that was that common
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On a 30g Carbohydrate per day diet, then about 40 to 70% of your energy needs to come from fat (if you stick to the RDA of protein (10% to 35% of your kcal).

If you're only eating 5g of carb per meal (as per the study) then that could be as high as 80%.

It is a bit fat heavy, but (by doing the maths) I must be eating at least 200g of fat per day on my diet so 75g for a single meal doesn't sound completely unreasonable.
 
Re: Warwick Uni: Diabetics urged to steer clear of high fat

I said it wasn't that common :lol:
 
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