bellabella
Well-Known Member
- Messages
- 136
- Type of diabetes
- Type 1
- Treatment type
- Insulin
Yes. You can get two messages across in 25 mins. Perhaps even just one.There isn't a lot you can do in 25 minutes.. I would "waffle" the D basics & weed out the yawners the hangover merchiants & the arrogance...
Then point who is left to this site to glean knowledge from the likes of @Spiker ...
Hi. I agree with Spiker and. Smidge. T1 can come on at any age and many HCPs don't know this and just assume T2 if older. The latest NICE Draft DEC 2014 Diabetes Guidelines now, sensibly, suggest the GP assumes T1 as a possibility if the patient presents as slim and having had weight loss as I did. It also says that the two tests GAD and c-peptide need to be used with care (if used) as GAD is only reliable at or near the time of diagnosis and c-peptide becomes more relibale as the condtion progresses. Note that GAD antibodies are not the only cause of T1 things like viruses, pancreatitis and so on can cause iselt cell damage. To me one of the important differences between a typical T2 and a typical T1 is that aT2 will have too much insulin whereas a T1 will have too little. This means the tablets and insulin if needed need to be chsoen with that in mind.
Good question. This point has appeared in the latest NICE Draft DEC 2014 Diabetes guidleines. I had my GAD and c-peptide done privately 8 years after diagnosis as my GP wouldn't accept I was anything other than a T2 despite never having been overweight in my life and all tablets failing. My GAD was negative but my c-peptide showed I had very little insulin; indicative of failing islet cells. GAD isn't the only cause of islet cell death and I'm suspicious I may have had a virus. At the end of the day the c-peptide test indicates the right treatment needed whereas GAD shows the possible cause not the right treatment? The new guidelines sensibly say being slim is a strong indicator of LADA at diagnosis.Does that mean that my GAD test won't be reliable as I've had diabetes for around 10 years?
Good question. This point has appeared in the latest NICE Draft DEC 2014 Diabetes guidleines. I had my GAD and c-peptide done privately 8 years after diagnosis as my GP wouldn't accept I was anything other than a T2 despite never having been overweight in my life and all tablets failing. My GAD was negative but my c-peptide showed I had very little insulin; indicative of failing islet cells. GAD isn't the only cause of islet cell death and I'm suspicious I may have had a virus. At the end of the day the c-peptide test indicates the right treatment needed whereas GAD shows the possible cause not the right treatment? The new guidelines sensibly say being slim is a strong indicator of LADA at diagnosis.
Does that mean that my GAD test won't be reliable as I've had diabetes for around 10 years?
Yes, the DAFNE course should be a MUST for all type 1s. Also please treat everyone as an individual as insulins all react differently in us all. Don't rush to put people onto Levemir and Lantus as some diabetics cannot tolerate these insulins.....they almost did me in and I suffered like hell for 3 years until I began treating myself using my daughter's Insulatard.I have a teaching session with medical students in a couple of weeks. I have 25 minutes to talk to them about type 1 and living with it. What would you like your Dr's to know? What should I cover?
Many confuse Type 1 and 2 so I thought I'd cover the difference and awareness of hypos but any ideas otherwise?
GAD tests are pretty reliable, but they are only a one-way diagnostic tool i.e. a positive GAD test is indicative of an auto-immune form of diabetes, but a negative one tells you nothing except that there are no GAD antibodies visible at that moment - that's what confuses people and why medics don't like the test. Incidentally, they rarely just test for GAD antibodies; they test for 3 or 4 different islet cells and antibodies - people just refer to the test as GAD for short.
C-peptide is OK as a test to see if you need insulin treatment - but it is not a diagnostic test. It cannot differentiate between different types of diabetes - it just indicates the level of insulin you are producing. In the early stages of Type 2 you are likely to be producing too much insulin so you would have a high c- peptide and high BG; in the early stages of LADA you are likely to be producing insulin at the low end of normal - they will often use that difference to diagnose, but as we never know what stage Type 2s and LADAs are at, it's all a bit hit and miss. As the illnesses progress unchecked, both groups will produce progressively less insulin because high BG is toxic to beta cells. That doesn't mean Type 2s have become LADAs or vice versa, but both will have the same symptoms.
GAD and c-peptide tests should be done and the results interpreted together to get a clearer picture. However, personally I had to plump for one test so it was the GAD as I wanted a proper diagnosis - by then, I could already tell I wasn't producing enough insulin and needed to inject, so the c-peptide test would have done nothing except confirm that.
Smidge
Thanks. Interestingly there is another thread running about users of these forums not being experts whereas GPs and DNs are. I think the fact that your DN needed to lookup c-peptide doesn't show she/he is not a good DN but they have to handle so much information on every aspect of medicine that they are not always experts but sometimes we are.I was slim when first diagnosed but had been overweight beforehand, spent most of my adult life fighting the flab.
When I had my blood taken this morning I checked with the nurse that she had the right tests, I'd originally booked just for the AC1, and she said the GAD test, nothing about c-peptide! I had to get her to look it up to see that both were needed, there was nothing on my notes about it but luckily she was able to add it at the last minute.
I don't have a lot of faith in the surgery at the moment but being in a village there isn't another surgery I can go to - the nearest town surgery also runs my village one so it has the same doctors!
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