As type 2s don't generally get any testing of their insulin resistance and don't have a DNA analysis done at diagnosis, such statements are as trustworthy as saturated fat is a killer and smoking helps to clear the lungs.
You stated that the extract is from a blog. I believe that saying something on a blog is an opinion not advice, and should not be considered as such....... is giving dangerous advice .......
You stated that the extract is from a blog. I believe that saying something on a blog is an opinion not advice, and should not be considered as such
Well the question is what do you think about this opinion then? I mean it’s an opinion not a fact, an opinion isn’t a fact.You stated that the extract is from a blog. I believe that saying something on a blog is an opinion not advice, and should not be considered as such.
Wow this is an amazing reply, really enjoyed reading it. Thanks for taking the time to write such an amazing masterpiece! It was very informative.So, here then is a fact.
Everyone goes through a period of insulin resistance at least once in their lives. You, @Ali Akin have just come through it, it's called puberty. You have to overcome insulin's control of energy in order to grow at the rate needed. Pregnancy is another such period, which is why gestational diabetes is a thing. (for some people, according to their genetic disposition and gene expression via epigenetics, and environmental impact on that)
If it was as simple as "having the genes for it" - then you would expect out of a population, some would go through puberty and some would be stuck in childhood. Maybe that's correct, but my opinion is that it's unlikely.
The problem with insulin resistance, is that it's complicated. Every cell in your body has an interaction with insulin, and insulin has over 100 jobs to do throughout your body. Dealing with blood glucose is only the best-known effect, and even that has wildly different effects on different tissue types. Then - there are large numbers of processes that drive insulin resistance at the cellular level that have nothing to do with glucose. Fructose (and it's cousin, alcohol) will directly drive insulin resistance in visceral adipose tissue by causing the mass production of ROS and cytokines due to hypertrophy - and the effect of that is the meta increase in insulin resistance around the body (simply requiring more of a thing to do the same job) - you have to understand the effects at cellular, organic and whole-body level. I've been studying hard on this all year, and only know that I know very little.
However - my solid opinion is that anyone who suggests that there is a "gene" for dealing with insulin resistance, firstly doesn't understand anything about genetic expression and how translation factors work, or anything about epigenetics at all, because it's such a reductive over-simplification that it's practically meaningless. And that's before you consider how unlikely it is that we evolved a genetic switch to flip something as fiendishly complicated (and necessary) as all the things that insulin does.
But - as humans - we like a simple story, especially a simple story that sound convincing - and that's really what the sentence you stared with is - it's just very out of date, and lacking in understanding of genetics and insulin resistance.
Is this to do with your course work? If it is, you certainly are receiving plenty of useful information.“If you do not have the genes for insulin resistance, you can not become diabetic, even if you gain weight”
What do you think about this statement. Btw this statement was made by a cardiologist, NOT an endocrinologist or anything so keep that in mind. He is a cholesterol expert. I think it’s very important to have the ability to be able to interpret information properly on the internet.
Nah I just am just involved with this stuff for fun, for my own health. It’s just an interest or mine really.Is this to do with your course work? If it is, you certainly are receiving plenty of useful information.
Yea I totally understand man! Just I am very interested in human metabolism and health. I personally had a big health scare with my Liver, it had lots of fat in it, which we know is related in the development of insulin resistance, prediabetes, type 2 diabetes etc. And this problem of Fatty Liver happened at a young age, due to me being obese. Luckily I managed to reverse the fatty liver by just a weight loss of 28kgs. So now like for the rest of my life I want to be careful of my weight and general health, the mantra is if I keep this weight for the rest of my life I will be fine. For me the issue was quite mild so I didn’t cut out carbs I just did a calorie deficit really. But yea I get what you mean totally it wasn’t easy managing my own health issues too, loosing the weight wasn’t easy.Just try to remember that it's much more than that for many members of this forum. Getting accurate information, and sometimes just basic human encouragement, can make all the difference between just hanging on, and turning this thing around. You will appreciate that it's very much not fun for many on here.
I do get that. But as @Chris24Main describes it is so complicated and to trawl through the medical jargon to understand it all. For some, it is too much. Opinion of their medical doctors are important in treatment.Yea I totally understand man! Just I am very interested in human metabolism and health. I personally had a big health scare with my Liver, it had lots of fat in it, which we know is related in the development of insulin resistance, prediabetes, type 2 diabetes etc. And this problem of Fatty Liver happened at a young age, due to me being obese. Luckily I managed to reverse the fatty liver by just a weight loss of 28kgs. So now like for the rest of my life I want to be careful of my weight and general health, the mantra is if I keep this weight for the rest of my life I will be fine. For me the issue was quite mild so I didn’t cut out carbs I just did a calorie deficit really. But yea I get what you mean totally it wasn’t easy managing my own health issues too, loosing the weight wasn’t easy.
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