What's the impact of Omeprazole on type 1 diabetics

Been on omeprazole myself and just recently diagnosed in hospital.

Had a pretty intensive screening from consultant and head pharmacist.

Neither mentioned anything in relation to this drug.

Not exactly the answer to your question but hope it gives you a bit more insight.

Hi there .. Ive been on the ....zole family for over 20 years and its effect on my numbers has for the most part been so insignificant that my Diabetic Specialist just skims over it when we do my annual medicines review. Given that I have 17 items on repeat prescription it may be he is happy I am coping with it OK but as I have had Lansoprazol and every generic variant thro Osemaprazole and I think 3 or 4 other members of the ...zole family over the years at least twice in 20+ years.

As I think that there would be well documented articles if there was anything for you to worry about!!! but .. I would advise you speak to a Diabetic specialist rather than your GP if you still have any concerns.

Hope this allays your fears a bit but you need to find what affects YOU!!! We all cope with this in our separate ways and we will try to help you to answer questions but we can only advise through our own experiences as we are, mainly, just sufferers like you and not Medics!!!

Good luck .... Mike

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Could possibly be delayed stomach emptying due to nerve damage - you should see your diabetic team about it.

Very fair comment Robert as the .....zoles can have a delaying effect on.bowel movements as well as their settling of griped etc

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lukkymik said:

Very fair comment Robert as the .....zoles can have a delaying effect on.bowel movements as well as their settling of griped etc

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That's interesting - I've been on Omeprazole for about a year for reflux, which coincided with poor digestive transit for which I was given Domperidone. More recently it was suggested I had early nerve damage, but I don't get the hypo from delayed stomach emptying, so I wonder if it's all down to the Omeprazole.

I find it makes me feel generally a bit drowsy and sometimes feel a bit sweaty, but as I take numerous other tablets at the same time, I can't be sure it's the MUPS. I make sure I eat before taking it, but before I had this I did have gastro-refux problems and would often be sick immediately after a meal or a glass of water. Never noticed a difference personally re: blood glucose levels, but as I'm able to keep my food down consistently, this will ensure I'm not losing vital fluids and dehydrating. I did require a bowel resection, due to a pancreatic blood clot and lost 2 mtrs of dead bowel nad have to take warfarin now and have bi-weekly blood tests to ensure my blood viscosity/coagulation/clotting levels are within range.
Good luck in finding an answer, I'd be interested to find out too.

Mart.

It is a proton pump inhibitor and can help improver overall diabetes control
http://www.diabetesincontrol.com/studie ... od-glucose

I take half dose (15mg) lansaprozole for reflux and it certainly knocks about 0.3-5 off my HbA1c :thumbup:

i have been a type 1 brittle diabetic since I was 22 months old. Have learned a lot about collecting data from my body over the years. My cardiologist saw me on May 31 and put me on omeprazole DR 25 MG and allodipine 205MG to try to find out why I am having chest pains in various areas. For the last 1 1/2 weeks I have noticed that the carb absorption is very slow and when I get sonething to eat to correct the low, it is still not absorbed. Having been at this for so long, I know what works fast. For low's that set on quickly and drop fast. I use straight karo syrup. Even tht is not working quickly. and by the time it does, it doesn't take long for the blood sugar to rise over 200 and often gets to almost 300 before it stops. They say it doesn't block carb absorption, but it has happened too many times in the last 10 days for me to believe that it doesn't. any theories on the matter.

I asked my Doctor about this a fortnight ago as I have had to raise my dose of Omeprazole to 40mg daily to help heal an ulcer. The Doctor didn't seem to think it would make any difference at all despite my concerns that I was experiencing a lot of low blood glucose readings and told me to speak to the Colonscopist? in 6 weeks time at my next Colonscopy examination. My Diabetic Nurse also said the same when I asked if Omeprazole affects absorption of carbs etc. I was diagnosed as T1D in October 2022, but have been taking Omeprazole daily for nearly 15 years so feel I know how the tablets affect me, but now having to test my blood glucose regularly I am concerned about the range of readings I get especially before and after meals.
I will post anything I find out in the next few weeks and will also keep an eye on this thread for any information anyone else provides.

littlesoldier01 said:

I've been taking Omeprazole for the past 5 years for stomach acid reflux issues and am concerned that the delay in digestion is causing my blood sugars to increase a few hours after eating and after my fast acting insulin has been most effective. Has anyone else noticed this?

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Type 1 diabetics also suffer from gastroparesis where nerve damage delays the emptying of the stomach causing unexpected highs later on and possibly low blood sugars immediately.
I've got a good friend and she is able to manage the situation with careful timing of doses using a pump etc. Obviously you need to get this confirmed by a gastroenterologist if you suspect this is the case.
Omeprazole reduces stomach acid but you do need your hydrochloric acid to properly digest food so may be worth investigating whether you could gradually reduce that by supplementing with digestive enzymes//leicithin granules (Holland and Barrett? As you age you make less stomach acid and this what causes reflux because the stomach 'bag' doesn't close if the food isn't properly digested. I realise that reducing the acid improves the symptoms but as you suspect it likely is making digestion worse too at a time when you need your protein, minerals , fats and vitamins from food more than ever!

littlesoldier01 said:

Obviously meant 3hrs!

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Sounds very much like Gastroparesis

Oral pills and supplements do not disssolve due to the reduction in stomach acid. Vitamins and iron tabs and any extended release or delayed release meds may pass thought the canal untouched. My Metformins used to come out looking like they went in. Vitmin C absorbtion is affected. Special care must be taken with antibiotics which lose effectiveness.

There are warnings by the FDA not to take these meds for longer than 14 days and not repeat this within 4 months interval. They also say do not take this drug (Omeprazole) if also taking
- warfarin (blood-thinning medicine)
- prescription antifungal or anti-yeast medicines
- diazepam (anxiety medicine)
- digoxin (heart medicine)
- dextrose (hypo treatment)
None of these warnings appear in the UK information.

Omeprazole is contra-indicated with alcohol intake and aspirin use since this may lead to an increase in irrritation of the stomach or bowel linings due to the slowed transit time. peptic ulcers are at increased risk.
The use of this med if your stools are black or tarry naturally or from say iron supplements requires special monitoring since these mask the chance of observing blood in the stools due to the irritation.

Some good news - use of a PPI may lead to a breathalyser test giving a false negative.