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Fasting
where does it come from?
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<blockquote data-quote="Widgets" data-source="post: 2475010" data-attributes="member: 545952"><p>Think of the liver as a really eager, helpful, chemicals factory making and removing things as it thinks best. When I was training (not a medic but medicine adjacent) the number quoted in our lecture was '300 separate chemical processes', but that was 30 years ago so I'd guess a lot more have been found since then. </p><p></p><p>The specific answer to 'where does the liver get glucose?' seems to be:</p><p>"During short-term fasting periods, the liver produces and releases glucose mainly through glycogenolysis. During prolonged fasting, glycogen is depleted, and hepatocytes synthesize glucose through gluconeogenesis using lactate, pyruvate, glycerol, and amino acids"</p><p></p><p>From this paper: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050641/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050641/</a></p><p>Section 1.2 Gluconeogenesis</p><p></p><p>I'm finding all of this biochemistry stuff fascinating, as well as really frustrating in my own, personal, science project (aka my body)</p></blockquote><p></p>
[QUOTE="Widgets, post: 2475010, member: 545952"] Think of the liver as a really eager, helpful, chemicals factory making and removing things as it thinks best. When I was training (not a medic but medicine adjacent) the number quoted in our lecture was '300 separate chemical processes', but that was 30 years ago so I'd guess a lot more have been found since then. The specific answer to 'where does the liver get glucose?' seems to be: "During short-term fasting periods, the liver produces and releases glucose mainly through glycogenolysis. During prolonged fasting, glycogen is depleted, and hepatocytes synthesize glucose through gluconeogenesis using lactate, pyruvate, glycerol, and amino acids" From this paper: [URL]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050641/[/URL] Section 1.2 Gluconeogenesis I'm finding all of this biochemistry stuff fascinating, as well as really frustrating in my own, personal, science project (aka my body) [/QUOTE]
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