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why does normal Bg make me feel hypo?
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<blockquote data-quote="MushyPeaBrain" data-source="post: 648057" data-attributes="member: 27914"><p>[USER=125618]@this is too difficult two[/USER] I found medical research papers discussing it when I was researching to try and understand what had happened to me. The sudden tighter control of my BG triggered retinopathy in both my eyes. Some consultants/eye specialists are aware of this but many aren't.</p><p> </p><p>One study (Brinckmann-Hansen, 1988) has even shown that if the improved blood sugar control after rapid tightening of blood sugar levels is maintained for nearly 3.5 years, there is never any improvement of the initially worsened retinopathy. Presumably this means that the damage done by the initial rapid improvement in blood sugar levels will never be corrected. That study also showed that changing blood sugar levels were more damaging to the body than stable levels, even if those stable levels were higher (p. 1245). The body seems more interested in glucose homeostasis than in normal blood sugar.</p><p>Brinckmann-Hansen compared the worsening of retinopathy in those with standard insulin therapy, multiple daily insulin injections, and with an insulin pump, and found moderate worsening in all three groups, despite the rapid tightening of hyperglycemia in the latter two groups. Three months into the study, the only group with a statistically significant worsening of retinopathy were those using the insulin pump (p. 1244, figure 2).</p><p>Sources: F. Zaccardi, "Glycemic Risk Factors of Diabetic Vascular Complications: The Role of Glycemic Variability," Diabetes Metabolism Research and Review, vol. 25, no. 3, p. 199 (2009); O. Brinckmann-Hansen, et al, "The Response of Diabetic Retinopathy to 41 Months of Multiple Insulin Injections, Insulin Pumps, and Conventional Insulin Therapy," Archives of Ophthalmology, vol. 106, no. 69, p. 122 (1988); M. Leow and J. Wyckoff, "Under-Recognized Paradox of Neuropathy from Rapid Glycemic Control," Postgraduate Medical Journal, vol. 81, no. 952, p. 103 (2005).</p></blockquote><p></p>
[QUOTE="MushyPeaBrain, post: 648057, member: 27914"] [USER=125618]@this is too difficult two[/USER] I found medical research papers discussing it when I was researching to try and understand what had happened to me. The sudden tighter control of my BG triggered retinopathy in both my eyes. Some consultants/eye specialists are aware of this but many aren't. One study (Brinckmann-Hansen, 1988) has even shown that if the improved blood sugar control after rapid tightening of blood sugar levels is maintained for nearly 3.5 years, there is never any improvement of the initially worsened retinopathy. Presumably this means that the damage done by the initial rapid improvement in blood sugar levels will never be corrected. That study also showed that changing blood sugar levels were more damaging to the body than stable levels, even if those stable levels were higher (p. 1245). The body seems more interested in glucose homeostasis than in normal blood sugar. Brinckmann-Hansen compared the worsening of retinopathy in those with standard insulin therapy, multiple daily insulin injections, and with an insulin pump, and found moderate worsening in all three groups, despite the rapid tightening of hyperglycemia in the latter two groups. Three months into the study, the only group with a statistically significant worsening of retinopathy were those using the insulin pump (p. 1244, figure 2). Sources: F. Zaccardi, "Glycemic Risk Factors of Diabetic Vascular Complications: The Role of Glycemic Variability," Diabetes Metabolism Research and Review, vol. 25, no. 3, p. 199 (2009); O. Brinckmann-Hansen, et al, "The Response of Diabetic Retinopathy to 41 Months of Multiple Insulin Injections, Insulin Pumps, and Conventional Insulin Therapy," Archives of Ophthalmology, vol. 106, no. 69, p. 122 (1988); M. Leow and J. Wyckoff, "Under-Recognized Paradox of Neuropathy from Rapid Glycemic Control," Postgraduate Medical Journal, vol. 81, no. 952, p. 103 (2005). [/QUOTE]
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