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Type 1 Diabetes
Your Thoughts On The Cause, Of Type 1 Diabetes
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<blockquote data-quote="tim2000s" data-source="post: 1875637" data-attributes="member: 30007"><p>Yet if you look at my family, I have auto-immune conditions going back to my grandmother (my great-grandparents both passed away 20 years ago so I can't confirm about them), and showing up in all of the members of my family. These show up as thyroid, vitiligo, rheumatoid arthritis, psoriasis and of course T1D. No-one as yet has displayed coeliac disease.</p><p> </p><p>Why do I mention this? Because the gut-permeability hypothesis is tightly linked with Coeliac as well as T1D, and in my family sample, we don't see any coeliac, which suggests that yet again, gut permeability is one of the drivers to trigger an autoimmune reaction linked to genetic predisposition, or it's symptom of genetic predisposition that has not been fully identified. </p><p></p><p>In other words, there's a lot going on in the identification of why Type 1 happens, and while gut permeability is currently a "topic du jour", I suspect that we'll arrive at a place where we find it's a combination of factors driven by environement and DNA. That just goes to show how little we know about it at the moment.</p></blockquote><p></p>
[QUOTE="tim2000s, post: 1875637, member: 30007"] Yet if you look at my family, I have auto-immune conditions going back to my grandmother (my great-grandparents both passed away 20 years ago so I can't confirm about them), and showing up in all of the members of my family. These show up as thyroid, vitiligo, rheumatoid arthritis, psoriasis and of course T1D. No-one as yet has displayed coeliac disease. Why do I mention this? Because the gut-permeability hypothesis is tightly linked with Coeliac as well as T1D, and in my family sample, we don't see any coeliac, which suggests that yet again, gut permeability is one of the drivers to trigger an autoimmune reaction linked to genetic predisposition, or it's symptom of genetic predisposition that has not been fully identified. In other words, there's a lot going on in the identification of why Type 1 happens, and while gut permeability is currently a "topic du jour", I suspect that we'll arrive at a place where we find it's a combination of factors driven by environement and DNA. That just goes to show how little we know about it at the moment. [/QUOTE]
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