Is (GTT diagnosed) Prediabetes actually a genetic trait?

[yetta2mymom]

My glucose tolerance test 1964 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100 (referred to as a glucose tolerance test for prediabetes). I have never had a high A1C or fasting blood sugar. A relative was informed that they were sure to become a diabetic in 2 years or less over 30 years ago (still going strong). A weight loss doctor (PBS, public television in U.S.) drew my type GTT and said these people (about 1/10 of his volunteers) did not lose weight on his weight loss program. He called it the hunter gene (checking to see if I can find out his name). I do not lose weight on an Atkins style diet.

My theory: People who have been called prediabetics (glucose tolerance test) actually have a gene(s) which leads them to postpone processing sugar until there blood sugar rises (what this means is unknown). This would be good in famines and if you eat an Atkins style diet. One of the downsides seems to be that you become more susceptical (word?) to diabetes.
Can someone give me the correct spelling?

 

[Lamont D]

It's all about the hormonal response to food or types of food especially carbs or sugars.
Different types respond differenly to hormonal imbalance problems.
Being prediabetic does not always mean that you will become diabetic, it all depends on what your diet is, even then, the progression cannot be stopped, but it is possible by eating a low carb high fat diet.
An oral glucose test tracks your response to glucose or mixed meal or a high carb breakfast from fasting beforehand. It is also a way to see different levels of composition of your blood through the test.

Hope this helps.

 

[Salvia]

Hi yetamymom

you nearly made it - should be susceptible - for future ref

 

[yetta2mymom]

It's all about the hormonal response to food or types of food especially carbs or sugars.
Different types respond differenly to hormonal imbalance problems.
Being prediabetic does not always mean that you will become diabetic, it all depends on what your diet is, even then, the progression cannot be stopped, but it is possible by eating a low carb high fat diet.
An oral glucose test tracks your response to glucose or mixed meal or a high carb breakfast from fasting beforehand. It is also a way to see different levels of composition of your blood through the test.

Hope this helps.

Hi

What does this have to do with anything? I do not have sugar problems. I simply have the glucose tolerance test which in my opinion has been read as insulin resistance but is actually a gene which is very good in famines (do not waste energy changing sugar into fat and storing sugar in the liver, simply use the sugar to run the body. This is fine if the amount of sugar ingested is low. If you think about it it is not surprising that this makes you more susceptible to diabetes. How the body does this and prevent the blood sugar from rising too much probably involves complicated chemistry which has lead to the misunderstanding of insulin resistance.) The advice given to people with the gene stands, but I obviously am lucky and have a compliment of genes so I have gotten away with all sorts of diets for 77 years as has a relative.

 

[Totto]

You are very close to full-blown diabetes and your ability to process carbohydrates is impaired. Good to hear you low carb as keeping carbs down will lower your risk of complications due to high BG.

 

[yetta2mymom]

It's all about the hormonal response to food or types of food especially carbs or sugars.
Different types respond differenly to hormonal imbalance problems.
Being prediabetic does not always mean that you will become diabetic, it all depends on what your diet is, even then, the progression cannot be stopped, but it is possible by eating a low carb high fat diet.
An oral glucose test tracks your response to glucose or mixed meal or a high carb breakfast from fasting beforehand. It is also a way to see different levels of composition of your blood through the test.

Hope this helps.

You are very close to full-blown diabetes and your ability to process carbohydrates is impaired. Good to hear you low carb as keeping carbs down will lower your risk of complications due to high BG.

Hi
(GTT glucose tolerance test is probably test you are talking about).
I have changed my theory to some people. I have bought an ad in the N.Y. Times about the fact that in 1957 I had an episode (as did my relative (virus?)) similar to what happens to people who end up with type 1 diabetes (trying to find fellow travelers) . One of my symptoms is if I eat a lot of sugar/starch/alcohol I can end up with the symptoms of a sudden drop of blood sugar many hours later, up to a near death experience. I eat an Atkins style diet (only protein, fat and low carb vegetables. I can expand my explanation for the small cheats I sometimes take none of them involve the normal amount of sugar and/or starch in the western diet) which controls all my symptoms (other symptoms can be described as 1/3 the symptoms of a bad case of chronic fatigue syndrome). I don't think I have the GTT which indicates insulin resistance (always normal A1C and fasting blood sugar) as these were my symptoms for many years (think 50 or more). Also as I indicated I do not lose weight (unless I do the normal cut calories increase exercise) on an Atkins (only protein, fat and low carb vegetables) diet. I am probably going to fund a study to follow women (take a base line GTT) who plan to get pregnant I suspect most of the ones who end up with sugar problems during and after pregnancy have the gene which gives you what is now described as prediabetic (high blood sugar 2 hours after taking the sugar for GTT) without any A1C or fasting blood sugar problems.

 

[Indy51]

Your symptoms sound very much like Reactive Hypoglycemia.

 

[yetta2mymom]

Your symptoms sound very much like Reactive Hypoglycemia.

Your symptoms sound very much like Reactive Hypoglycemia.

Hi

Then why was I rejected for treatment by the Joslin Dibaetic Clinic's expert on reactive hypoglycemia. The one they talk about has immediate effects and is not controlable with an Atkins diet. I have not found anyone except my relative with this symptom.

 

[yetta2mymom]

Hi

After feedback I have updated an ad I will probably place in the N.Y. Times Science Section (better explanation).


I have the following facts.

My glucose tolerance test 1964 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100 (diagnosis prediabetic assumed insulin resistant). I have never had a high A1C or fasting blood sugar. A relative was informed that they were sure to become a diabetic in 2 years or less over 30 years ago (still going strong). A weight loss doctor (PBS, 2015) drew my type GTT and said these people (about 1/10 of his volunteers) did not lose weight on his weight loss program. He called it the hunter gene (checking to see if I can find out his name). I do not lose weight on an Atkins style diet.

My theory 2 separate conditions: Some people who have been called prediabetics actually have a gene(s) which leads them to postpone processing sugar until there blood sugar rises (what this means is unknown). This would be good in famines and if you eat an Atkins style diet. One of the downsides seems to be that you become more susceptible to diabetes.

For people in Great Britain PBS is public television in the U.S.

 

[Lamont D]

Hi, I can see that your theory does work.
I have 'late' reactive hypoglycaemia.
The difference between us is that I hypo up to four hours or so later.
There are many variants of RH as there is of diabetes even within types.
So many blood glucose disorders are individual.

Many of these rare types are very difficult to diagnose plus you have the fact that not many doctors even specialist endocrinologists have little or none experience of the condition.

If you can read the RH forum you will see similarities between the different posters and the differences but the treatment is always the similar which is avoid carbs and sugars as much as possible, avoid low fat and manufactured food. Eating small meals often helps.

I am constantly in ketosis, this has real health benefits for me and others.
But it is individual and what suits you. I eat lots of fatty meats and salad veg mostly.
I work full time, and have loads of energy and have lost loads of weight.

My hba1c is normal.
I always record high numbers after glucose then hypo later on.

There is a RH condition called flat response RH. No matter the intake the levels don't rise but hypo later.
There is gastric dumping, which disposes of glucose then glucagon very quickly and hypos within two to three hours after.

I really don't think an Atkins style approach is the best option in my experience.
Just eating very low carb is preferable. Atkins is supposed to be for a short term weight loss diabetes treatment not a life time lifestyle change.

 

[yetta2mymom]

Hi, I can see that your theory does work.
I have 'late' reactive hypoglycaemia.
The difference between us is that I hypo up to four hours or so later.
There are many variants of RH as there is of diabetes even within types.
So many blood glucose disorders are individual.

Many of these rare types are very difficult to diagnose plus you have the fact that not many doctors even specialist endocrinologists have little or none experience of the condition.

If you can read the RH forum you will see similarities between the different posters and the differences but the treatment is always the similar which is avoid carbs and sugars as much as possible, avoid low fat and manufactured food. Eating small meals often helps.

I am constantly in ketosis, this has real health benefits for me and others.
But it is individual and what suits you. I eat lots of fatty meats and salad veg mostly.
I work full time, and have loads of energy and have lost loads of weight.

My hba1c is normal.
I always record high numbers after glucose then hypo later on.

There is a RH condition called flat response RH. No matter the intake the levels don't rise but hypo later.
There is gastric dumping, which disposes of glucose then glucagon very quickly and hypos within two to three hours after.

I really don't think an Atkins style approach is the best option in my experience.
Just eating very low carb is preferable. Atkins is supposed to be for a short term weight loss diabetes treatment not a life time lifestyle change.

 

[yetta2mymom]

Hi

I have symptoms similar to 1/3 of a severe case of chronic fatigue syndorm without an Atkins diet. I had an autoimune type event (1957,think what happens when you end up with type 1 diabetes). My guess is that I have killed one type of cell in my adrenal glands and that has fouled up the release of enzymes used to process sugar. If you read my post I do not lose weight on an Atkins diet (I am 77) in fact my body rebels after awhile (a lot of sleep and rest, probable lowering of my normal body temperature).

 

[Lamont D]

Yep, I took that as an example of what has happened. It looks likely.
The process is so complicated and you would probably need a medical tricorder (from star trek) to actually discover what exactly happens.

Because I too have a rare condition, I can appreciate what is happening in your head, how and why this happens to you. And probably only you! I have been searching the web for answers since well before my diagnosis and because my particular condition developed naturally, even a best guess is probably nowhere close enough.

I wish I had answers for you, but only eating things that agree with you, will help.
That's it! No matter how or why, you have to do what makes sense to how your body works.

I have often wondered how I get enough vitamins and minerals that you need in my diet, but the more time I spend eating little or no carbs, I find my body is so much healthier. It might be just me, I've accepted that I'm weird, I've not given in by any stretch of the imagination, I'm still looking and what I'm doing works for me.
The search for knowledge is uppermost in my mind when I have time to research.

I have learned so much from this forum and its knowledgeable posters.
It's worth having have a look around.

 

[yetta2mymom]

Hi

You are talking to the wrong person. I am 77 years old. I had my autoimune? episode in 1957 (think type 1 diabetes). I had my glucose tolerance test in 1964 (the doctor said I was prediabetic (wrong does not lead to diabetes), prediabetes is defined as high blood sugar after 2 hours of the shot of sugar). At that time I looked at the GTT and figured out I could get low blood sugar many hours later if I ate too much sugar/starch/alchol. I modified my diet. This did not remove symptoms I now discribe as 1/3 the symptoms of a bad case of chronic fatigue syndorme. After about 50 years I went on an Atkins style diet (immediate success but it took several years for everything to clear). I do not lose weight on an Atkins diet (if I don't cut the calories and increase the exercise). You can see more if you look at this thread.

Neil

 

[Lamont D]

Hi
(GTT glucose tolerance test is probably test you are talking about).
I have changed my theory to some people. I have bought an ad in the N.Y. Times about the fact that in 1957 I had an episode (as did my relative (virus?)) similar to what happens to people who end up with type 1 diabetes (trying to find fellow travelers) . One of my symptoms is if I eat a lot of sugar/starch/alcohol I can end up with the symptoms of a sudden drop of blood sugar many hours later, up to a near death experience. I eat an Atkins style diet (only protein, fat and low carb vegetables. I can expand my explanation for the small cheats I sometimes take none of them involve the normal amount of sugar and/or starch in the western diet) which controls all my symptoms (other symptoms can be described as 1/3 the symptoms of a bad case of chronic fatigue syndrome). I don't think I have the GTT which indicates insulin resistance (always normal A1C and fasting blood sugar) as these were my symptoms for many years (think 50 or more). .

 

[yetta2mymom]

Of interest? I would help support a study ($) of what women’s GTT (glucose tolerance test) was before pregnancy. I would help support a study ($) of what the actual GTT of people with normal A1C is. Why?


I have the following facts.

My GTT 1964 70, ½ hr 130, 1 hr 175, 2 hr 185, extended 3 hr 100 (diagnosis prediabetic assumed insulin resistant). I have never had a high A1C or fasting blood sugar. A relative was informed that they were sure to become a diabetic in 2 years or less over 30 years ago (still going strong). A weight loss doctor (PBS, 2015) drew my type GTT and said these people (about 1/10 of his volunteers) did not lose weight on his weight loss program. He called it the hunter gene (anyone know his name?). I do not lose weight on an Atkins style diet.

My theory 2 separate conditions: Some people who have been called prediabetics actually have a gene(s) which leads them to postpone processing sugar until there blood sugar rises (what this means is unknown). This would be good in famines and if you eat an Atkins style diet.

 

[yetta2mymom]

Yep, I took that as an example of what has happened. It looks likely.
The process is so complicated and you would probably need a medical tricorder (from star trek) to actually discover what exactly happens.

Because I too have a rare condition, I can appreciate what is happening in your head, how and why this happens to you. And probably only you! I have been searching the web for answers since well before my diagnosis and because my particular condition developed naturally, even a best guess is probably nowhere close enough.

I wish I had answers for you, but only eating things that agree with you, will help.
That's it! No matter how or why, you have to do what makes sense to how your body works.

I have often wondered how I get enough vitamins and minerals that you need in my diet, but the more time I spend eating little or no carbs, I find my body is so much healthier. It might be just me, I've accepted that I'm weird, I've not given in by any stretch of the imagination, I'm still looking and what I'm doing works for me.
The search for knowledge is uppermost in my mind when I have time to research.

I have learned so much from this forum and its knowledgeable posters.
It's worth having have a look around.

Hi
If you read my posts you will see that you might have the hunter gene since one of my symptoms is very similar to yours. It makes sense that the problems of most people with reactive hypoglucemia would be different from the small (not that small) with the hunter gene.

Neil

 

[Lamont D]

Hi, having scanned the medical internet, yes, there are a couple of similar symptoms but I believe that I don't have that gene, it just doesn't fit.
RH symptoms are plenty and similar to many conditions.
That's why RH ers need lots of diagnostic tests to ascertain the condition.

I believe that there are many more with RH but haven't been diagnosed because the symptoms .mimic so many other conditions and the ignorance of GPs.

 

[yetta2mymom]

Hi, having scanned the medical internet, yes, there are a couple of similar symptoms but I believe that I don't have that gene, it just doesn't fit.
RH symptoms are plenty and similar to many conditions.
That's why RH ers need lots of diagnostic tests to ascertain the condition.

I believe that there are many more with RH but haven't been diagnosed because the symptoms .mimic so many other conditions and the ignorance of GPs.

Hi

I miswrote. I was meaning (on second thought) that I think that doctors have not as yet recognized that you can have subtle problems with your adrenal glands which fouls up the timing of the enzymes necessary for processing sugar. I happen to have a much more easily diagnosed (also worse) problem (since autoimmune episode in 1957, but I could only figure things out when this strange internet thing became ubiquitous). All my tests are negative but my symptoms aren't.

 

[Lamont D]

That's weird, just like me. All my tests are negative, and I get all the symptoms, when in hypo hell. Except that I go hypo, if I eat a certain amount of food that doesn't agree with my endocrine and digestive system.
What's even more weird, contrary to all the dietary experts, is that I shouldn't be able to function and be really ill because I don't eat a certain amount of 'good' or 'complex' carbs.
I'm not!
I'm fitter and healthier and so full of energy. Than I have been for decades!
Go figure!

Hi

I miswrote. I was meaning (on second thought) that I think that doctors have not as yet recognized that you can have subtle problems with your adrenal glands which fouls up the timing of the enzymes necessary for processing sugar. I happen to have a much more easily diagnosed (also worse) problem (since autoimmune episode in 1957, but I could only figure things out when this strange internet thing became ubiquitous). All my tests are negative but my symptoms aren't.