hi my mother had diabetes mellitus and was takeing 4 tablets of metformin tablets she had heart disease that the docter new about and high blood pressure. it says in the leflet for metformin that it can cause heart disease and a heart attack and death my mother died of heart dissease and diabetes mellitus in 2009 and kidney failure i beleave she should have not been takeing 4 tablets of metformin that the docter told her to take she should have been takeing only one metfomin tablet