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Go here —> https://www.diabetes.co.uk/forum/th...y-a-root-cause-of-autoimmune-diabetes.154040/My goodness where has the research been
Let’s get to the root, even if it hurts.
Go here —> https://www.diabetes.co.uk/forum/th...y-a-root-cause-of-autoimmune-diabetes.154040/My goodness where has the research been
Nope, due to my hiatus, I've been out of the loop (excuse the terrible pun!) on things on here recently. I'd certainly like to hear what @tim2000s has been up to, if it's software related, I might be able to help!
I gather the hookworm infection is treated once the specific part of the immune system has been activated. And thank you for your explanation. Hope springs eternal !!Interesting question. The answer essentially is that it is possible. This trial is probably in coeliac because it is less complicated- gluten causes immune cells to release antibodies that damage the epithelial cells. You can monitor this well. However with T1 there are so many different factors, until very recently we didn't know the structure we respond to etc. T1 is also more complicated to treat- we would need to regenerate or transplant beta islet cells, and then use this method to stop the response against them.
Using hookworm is difficult because that infection in itself is unpleasant and immune suppression is not the only consequence. Although on balance most would argue worth it. What many people are working to do is to isolate what chemical released from hook worm and the like causes immune suppression and use that on its own.
I am suggesting an international joined up approach. I believe "we" have the right mix of ingredients. Being in IT I know we have the compute power (many years ago exponential amounts (Big Blue for example); and I feel the nano engineering capabilities are there as well as the potential intelligence - we just need the politics, will and bodies to come together. I take your point on the pecking order issue.
I gather the hookworm infection is treated once the specific part of the immune system has been activated. And thank you for your explanation. Hope springs eternal !!
I got very excited by the smart insulin possibility wished this was on the horizon.I write software for clinical research; not infection, but oncology & respiratory mostly, as well as some diabetes research. Finding a cure, as in a biological one that reverses the immune attack on the pancreas, is incredibly hard and I reckon is possibly decades away. Add to the complexity, it takes 10 years and $1bn to bring a drug to market, as mentioned already.
The short term hope, and one that I am getting frustrated with, is the Artificial Pancreas. It seems to be taking ages; I would've expected something on the market by now. It's as good as a cure for me, as it takes away the management of diabetes.
Other "cures", are Smart Insulin that becomes active once it encounters blood glucose and stem cells; both of which are far off, but closer than a cure of the immune system, in my opinion.
But, yeah, I've had enough of diabetes now too and I've "only" had it for 15 years.
It is not only the beta cells, that are the tart target site within the pancreas, there is a bunch of molecules and enzymes, that got attacked, which makes it really nasty, because those exist in other parts of the body as well and get attacked there. So it’s not just the beta cells.if we trigger the immune system to stop attacking the pancreas beta cells, then what? Do they regrow? Do we need transplants, there is a monumental task in curing type 1 diabetes