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weird results from the Weizmann Institute 2015

Freema

Freema

Expert
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7,346
Location
Denmark
Type of diabetes
Type 2
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Diet only
https://wis-wander.weizmann.ac.il/l...37QClV4zW3Y474FoJ3uI1_u37t2KPK3uVSc2Yi0o2H1QQ

in this experiment with food contributing to blood glucose levels some weird results emerge... have any of you seen and discussed those results previously... where is seems to be the case that one person spiukes from bananas but not from cookies... and the other persons spike is totally the opposite.. what can be going on here I wonder... ?

Can any of you give me a hint or explanation
 
Individuality? Level of insulin resistance? Levels of insulin production?
 
Freema said:
https://wis-wander.weizmann.ac.il/l...37QClV4zW3Y474FoJ3uI1_u37t2KPK3uVSc2Yi0o2H1QQ

in this experiment with food contributing to blood glucose levels some weird results emerge... have any of you seen and discussed those results previously... where is seems to be the case that one person spiukes from bananas but not from cookies... and the other persons spike is totally the opposite.. what can be going on here I wonder... ?

Can any of you give me a hint or explanation
Click to expand...

It could be a case, or cases, of food intolerances. Most people a food or foods have I call their "rocket fuel".
 
Freema said:
Can any of you give me a hint or explanation
Click to expand...

A report I read on that research suggested that different gut microbiomes were behind the difference. Something that can change as evidenced after taking antibiotics or indeed the taking of pre/probiotics.
 
thanks to all of you for your answers... I think I am going to experiment more to find out more of my individual NO-goes and CAN-haves anyway... I think the gut-bacteria influence is very possible and then genes could maybe also be of more importance in what choices our individual body allows in as good fuel.... ...it is very peculiar that some don't spike on cookies or bananas...
 
Freema said:
thanks to all of you for your answers... I think I am going to experiment more to find out more of my individual NO-goes and CAN-haves anyway... I think the gut-bacteria influence is very possible and then genes could maybe also be of more importance in what choices our individual body allows in as good fuel.... ...it is very peculiar that some don't spike on cookies or bananas...
Click to expand...
A slight cautionary note. Just because something doesn't spike you too much once doesn't necessarily mean it should become a daily staple. Secondly I believe that current research is showing that the gut microbiome is a lot more dynamic than was previously thought and that changes in food types can have a significant effect in quite a short time span. Watch out!
 
Thank you @Freema, a fascinating study which appears to turn certain assumptions on their head !!
It does makes one wonder about the Glycaemic Index and Glycaemic Load values for various foods and how these values were obtained. There are of course ranges of GI for a given food say, bananas at GI of 51 +/- 2, does not give much leeway.
So as others have said, some possible explanations might be variation in insulin resistance (?weight, medications, undiagnosed pre-diabetes etc), and in gastric emptying times.
To postulate microbiome as a cause would suggest that the microbiome is sending some form of signal to the mechanisms which influence insulin release or the effect of insulin. But if one is not producing insulin does the microbiome help in other ways such as with timing of gastric emptying? Who knows?
 
Yes, gut microbes seem to be key. I think I posted this video about the study a while back.


Here's a Ted Talk by one of the study leaders:

 
kitedoc said:
Thank you @Freema, a fascinating study which appears to turn certain assumptions on their head !!
It does makes one wonder about the Glycaemic Index and Glycaemic Load values for various foods and how these values were obtained. There are of course ranges of GI for a given food say, bananas at GI of 51 +/- 2, does not give much leeway.
So as others have said, some possible explanations might be variation in insulin resistance (?weight, medications, undiagnosed pre-diabetes etc), and in gastric emptying times.
To postulate microbiome as a cause would suggest that the microbiome is sending some form of signal to the mechanisms which influence insulin release or the effect of insulin. But if one is not producing insulin does the microbiome help in other ways such as with timing of gastric emptying? Who knows?
Click to expand...

Personally, for me, I found the GI/GL to be white noise. I found the feedback from my meter (and later Libre) to be far more meaningful and informative.

All that said; I can understand how it could be very valuable for those using flexible exogenous insulins (as opposed to mixed) to have a "starter for 10" to ascertain when a blood sugar rise, or fall might occur, per foodstuff/drink. That said, again, a Libre or CGM is going to be far more personalised and useful that a generalised chart.
 
kitedoc said:
To postulate microbiome as a cause would suggest that the microbiome is sending some form of signal to the mechanisms which influence insulin release or the effect of insulin.
Click to expand...
Postulate - suggest or assume the existence, fact, or truth of (something) as a basis for reasoning, discussion, or belief.
It's a bit more than that. Research has been done in the Netherlands in 2013 where they studied the effects of infusing intestinal microbiota, from lean donors to male recipients with metabolic syndrome, on the recipients' microbiota composition and glucose metabolism. https://www.sciencedirect.com/science/article/pii/S001650851200892X?showall=true&via=ihub
More recently, still only 2016, research has been done at the University of Washington in Seattle investigating the mechanisms linking Gut Microbiome and Glucose Metabolism. Their conclusions suggest that more research is needed but Gut Microbiome seems to be a key player along with several other factors.
 
well yes of cause I am not going to eat too many carbs... but will be more experimenting, could by the way also make diabetes a bit more fun nerding with this kind of experimenting.
I think there are too many different experiments with gut bacteria lately that shows surprising influence on our bodies.. to look away from this phenomenon

but when it comes to experimenting with bananas I think it is a far too unstable food choice to know for sure how it constantly affects ones blood glucose... there is a lot of difference to eating an almost green banana to eating a very ripe black spotted banana... it is almost two different kinds of food..
 
I recall, a while ago now, watching one of those "Trust me I'm a Doctor" programmes where the were looking into why some folks appeared to consume all they encountered, yet retained sylph-like bodies, whereas others found their poundage increased at the drop of a hat. As part of the programme, they looked at one lady who had always been slim, until, as a result of some dreadful digestive lurgy her gut biome was trashed.

In an attempt to get her life back, she had a biome transplant which altered her life and health, but frorom then on she was much more prone to weight gain.

I can't recall all the details, so forgive me if I got some of the detail wrong, but the biome transplant then changed metabolism is accurate.
 
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