Was the Metformin taken at night or the or the previous morning. It makes a difference when it's taken and if it's extended release
Metformin HCL should be taken at night, with food.
Elizabeth Halprin, MD, clinical director of adult diabetes at Boston's Joslin Diabetes Center, explains why timing metformin HCL with the evening meal is so important. "In normal physiology, a person's liver often makes glucose overnight," she says. "So, it's not uncommon for a person to go to bed with a good blood glucose level and wake up with a higher one because their liver has been releasing sugar [all night]."