Hi Daibell. Could you please tell me what time of day you take your Metformin. I have been on SL for about three weeks now and am taking it in the evening but would prefer taking it in the morning with breakfast. Any comments please? Thank you.Hi. If you are already on Metformin SR (Slow Release) you will probably not notice anything. I've always been on SR so have never had a problem in 10 years even on max dose. If you and others have problems that don't fade after a few weeks then do insist on having the SR version which I find I can take at any time