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“Spikes” and Recovery
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<blockquote data-quote="JohnEGreen" data-source="post: 2197677" data-attributes="member: 223921"><p>"The term “glucotoxicity” refers to the detrimental effects of chronic exposure to supraphysiological glucose concentrations on the phenotype and function of β cells. The association of small increases in plasma glucose levels with dramatic loss of acute glucose-stimulated insulin secretion was first demonstrated in humans nearly 40 years ago.106 Since then, this finding has been confirmed in several animal models exposed to hyperglycemia including partially pancreatectomized,107 glucose-infused108 and neonatal diabetic rats,109 and in vitro cultured islets.110,111 Insulin secretion is considered to be the first function compromised by chronic high glucose levels in β cells. Yet, hyperglycemia has also been shown to lead to depletion of insulin stores together with decreased insulin gene expression."</p><p></p><p><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/glucotoxicity" target="_blank">https://www.sciencedirect.com/topics/medicine-and-dentistry/glucotoxicity</a></p><p></p><p>Another effect of raised blood sugar is high blood pressure as the glucose effects the blood vessels making them contract more vigorously.</p><p></p><p>I personally would not be complacent about spikes into the double figures even if reduced in the two hour period lack of damage may be assumed but is not certain I'd rather not take the chance if I don't need to especially not for a bowl of Weetabix.</p></blockquote><p></p>
[QUOTE="JohnEGreen, post: 2197677, member: 223921"] "The term “glucotoxicity” refers to the detrimental effects of chronic exposure to supraphysiological glucose concentrations on the phenotype and function of β cells. The association of small increases in plasma glucose levels with dramatic loss of acute glucose-stimulated insulin secretion was first demonstrated in humans nearly 40 years ago.106 Since then, this finding has been confirmed in several animal models exposed to hyperglycemia including partially pancreatectomized,107 glucose-infused108 and neonatal diabetic rats,109 and in vitro cultured islets.110,111 Insulin secretion is considered to be the first function compromised by chronic high glucose levels in β cells. Yet, hyperglycemia has also been shown to lead to depletion of insulin stores together with decreased insulin gene expression." [URL]https://www.sciencedirect.com/topics/medicine-and-dentistry/glucotoxicity[/URL] Another effect of raised blood sugar is high blood pressure as the glucose effects the blood vessels making them contract more vigorously. I personally would not be complacent about spikes into the double figures even if reduced in the two hour period lack of damage may be assumed but is not certain I'd rather not take the chance if I don't need to especially not for a bowl of Weetabix. [/QUOTE]
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